Literature DB >> 8507180

Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region.

T Kurihara1, K Kitamura, K Takaoka, H Nakazato.   

Abstract

A murine genomic clone of about 16 kilobases encompassing putatively entire bone morphogenetic protein (BMP)-4 gene has been isolated. Comparison with the cDNA clones revealed the existence of at least five exons on the 3' side of the clone. There are two alternative transcriptional start sites, one is for the first exon the other for the second, the resulting exon organization in mRNA is I-III-IV-V and II-III-IV-V, respectively. The coding region is dispersed between exons IV and V. Both promoter regions carry no canonical TATA box but carry GC rich sequences.

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Year:  1993        PMID： 8507180     DOI： 10.1006/bbrc.1993.1523

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Bmp4 is required for the generation of primordial germ cells in the mouse embryo.

Authors:  K A Lawson; N R Dunn; B A Roelen; L M Zeinstra; A M Davis; C V Wright; J P Korving; B L Hogan
Journal:  Genes Dev       Date:  1999-02-15       Impact factor: 11.361

2.  TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells.

Authors:  Nian-Ling Zhu; Changgong Li; Hao Hao Huang; Matthew Sebald; Vedang A Londhe; Nora Heisterkamp; David Warburton; Saverio Bellusci; Parviz Minoo
Journal:  Gene       Date:  2007-02-03       Impact factor: 3.688

3.  The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.

Authors:  N Gotoh; K Manova; S Tanaka; M Murohashi; Y Hadari; A Lee; Y Hamada; T Hiroe; M Ito; T Kurihara; H Nakazato; M Shibuya; I Lax; E Lacy; J Schlessinger
Journal:  Mol Cell Biol       Date:  2005-05       Impact factor: 4.272

Review 4.  Control of BMP gene expression by long-range regulatory elements.

Authors:  Steven Pregizer; Douglas P Mortlock
Journal:  Cytokine Growth Factor Rev       Date:  2009-11-08       Impact factor: 7.638

5.  Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing.

Authors:  Koichi Yano; Masatoshi Hoshino; Yoichi Ohta; Tomoya Manaka; Yoshifumi Naka; Yuuki Imai; Walter Sebald; Kunio Takaoka
Journal:  J Bone Miner Metab       Date:  2009-02-21       Impact factor: 2.626

6.  Identification of the control region of pancreatic expression of Bmp4 in vitro and in vivo.

Authors:  Mayu Yasunaga; Eiji Masui; Asami Oji; Atsumi Soma; Mitsuhiko Osaki; Tomoko Nakanishi; Kenzo Sato
Journal:  PLoS One       Date:  2013-04-23       Impact factor: 3.240

7.  Establishment and characterization of a transgenic mouse model for in vivo imaging of Bmp4 expression in the pancreas.

Authors:  Mayu Yasunaga; Nao Oumi; Mitsuhiko Osaki; Yasuhiro Kazuki; Tomoko Nakanishi; Mitsuo Oshimura; Kenzo Sato
Journal:  PLoS One       Date:  2011-09-15       Impact factor: 3.240

8.  An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud.

Authors:  Dolrudee Jumlongras; Salil A Lachke; Daniel J O'Connell; Anton Aboukhalil; Xiao Li; Sung E Choe; Joshua W K Ho; Annick Turbe-Doan; Erin A Robertson; Bjorn R Olsen; Martha L Bulyk; Brad A Amendt; Richard L Maas
Journal:  PLoS One       Date:  2012-06-12       Impact factor: 3.240
  8 in total

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