Literature DB >> 8506301

A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans.

J Yochem1, I Greenwald.   

Abstract

A >23-kb gene that encodes a large integral membrane protein with a predicted structure similar to that of the low density lipoprotein (LDL) receptor-related protein (LRP) of mammals has been isolated and sequenced from the free-living nematode Caenorhabditis elegans. The 4753-amino acid predicted C. elegans product shares a nearly identical number and arrangement of amino acid sequence motifs with human LRP, and several exons of the C. elegans LRP gene correspond to exons of related parts of the human LDL receptor gene. The existence of an apparent homolog of LRP in C. elegans offers the possibility of genetic analysis of the in vivo roles of LRP and of the relationship between protein structure and function in a simple model organism.

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Year:  1993        PMID： 8506301      PMCID： PMC46554          DOI： 10.1073/pnas.90.10.4572

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  44 in total

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3.  Structure of alpha 2-macroglobulin from the arthropod Limulus polyphemus.

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4.  Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans.

Authors:  J Austin; J Kimble
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5.  Genome linking with yeast artificial chromosomes.

Authors:  A Coulson; R Waterston; J Kiff; J Sulston; Y Kohara
Journal:  Nature       Date:  1988-09-08       Impact factor: 49.962

6.  Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

Authors:  R C Kowal; J Herz; K H Weisgraber; R W Mahley; M S Brown; J L Goldstein
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Authors:  A M Rose; D L Baillie
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8.  The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch.

Authors:  J Yochem; K Weston; I Greenwald
Journal:  Nature       Date:  1988-10-06       Impact factor: 49.962

9.  Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

Authors:  K Orth; E L Madison; M J Gething; J F Sambrook; J Herz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

10.  The minor myosin heavy chain, mhcA, of Caenorhabditis elegans is necessary for the initiation of thick filament assembly.

Authors:  R H Waterston
Journal:  EMBO J       Date:  1989-11       Impact factor: 11.598
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  27 in total

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Journal:  Mol Biol Cell       Date:  1999-12       Impact factor: 4.138

Review 7.  The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices.

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Review 8.  Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.

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9.  The Drosophila yolkless gene encodes a vitellogenin receptor belonging to the low density lipoprotein receptor superfamily.

Authors:  C P Schonbaum; S Lee; A P Mahowald
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10.  Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205
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