A chemical shift selective inversion recovery sequence for fat-suppressed MRI: theory and experimental validation.

Fat-suppression techniques are used extensively in routine proton nuclear magnetic resonance imaging to produce images free from chemical shift artifacts and dynamic range problems. A hybrid fat-suppression sequence is studied which combines the principle of short time inversion recovery with chemical shift selective imaging. The aim of this study is to provide a theoretical understanding of the role of the sequence parameters, as well as to compare this hybrid sequence with its most closely related conventional fat-suppression techniques, namely selective pre-saturation and short time inversion recovery (STIR) imaging. The hybrid technique is shown to be robust in normal use, and more tolerant than the conventional methods to mis-settings of parameters such as inversion time, as well as tip angle and frequency bandwidth of the fat selective pulse.