| Literature DB >> 8505645 |
R Whurr1, M Lorch, H Fontana, G Brookes, A Lees, C D Marsden.
Abstract
Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the fundamental frequency of the speech sample, indicating a reduction in the variability of pitch amongst patients. A total of 96% of patients' subjective diary reports showed an improvement with a median of 7 days to peak effect and a 5 week duration of peak effect.Entities:
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Year: 1993 PMID: 8505645 PMCID: PMC1015013 DOI: 10.1136/jnnp.56.5.526
Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN: 0022-3050 Impact factor: 10.154