| Literature DB >> 8505026 |
P Fernández1, A M Bermejo, M J Tabernero, M López-Rivadulla, A Cruz.
Abstract
A reverse-phase HPLC method for the determination of colchicine in biological fluids is proposed. Blood, liver and kidney colchicine concentrations were determined in rats at different times following intraperitoneal (i.p.) injection of 10 mg/kg of the drug. Colchicine was extracted from the samples studied using dichloromethane at pH 8. The dry extract was redissolved in the mobile phase and analyzed with simultaneous detection at 254 and 350 nm.Entities:
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Year: 1993 PMID： 8505026 DOI： 10.1016/0379-0738(93)90307-v
Source DB: PubMed Journal: Forensic Sci Int ISSN： 0379-0738 Impact factor: 2.395