| Literature DB >> 8503182 |
R Wickramasinghe1, J Meanger, C E Enriquez, G E Wilcox.
Abstract
Monoclonal antibodies against two virion proteins of the RAM-1 strain of avian reovirus neutralized virus infectivity; antibody against a 124-kDa (lambda B) protein caused broadly specific neutralization and antibody against a 39-kDa (sigma C) protein caused neutralization of greater type-specificity. The neutralizing activity of the monoclonals also exhibited host cell specificity: antibodies against the lambda B protein inhibited virus infectivity in Vero cells and not chicken kidney cells; one monoclonal antibody against the sigma C protein neutralized virus in only chicken kidney cells, whereas two other monoclonals against the sigma C protein neutralized virus in both Vero and chicken kidney cells but had greater neutralizing activity in Vero cells.Entities:
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Year: 1993 PMID: 8503182 DOI: 10.1006/viro.1993.1309
Source DB: PubMed Journal: Virology ISSN: 0042-6822 Impact factor: 3.616