| Literature DB >> 850246 |
T R Rodgers, M P LaMontagne, A Markovac, A B Ash.
Abstract
A series of 27 hydantoins was prepared and tested as antitumor agents. These were variously substituted in the 5 position but with special emphasis on the substituents (chloro, acetyl, chloroacetyl, and methyl) in the 1 and/or 3 positions. The most active compound was 5,5-bis(4-chlorophenyl)-1,3-dichlorohydantoin with a T/C value of 190% against P-388 lymphocytic leukemia in mice.Entities:
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Year: 1977 PMID： 850246 DOI： 10.1021/jm00214a031
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446