| Literature DB >> 850240 |
M C Wani, D H Rector, D H White, C G Pitt, G L Kimmel.
Abstract
A series of 7(8 leads to 11 alpha)abeo steroids was synthesized by a modification of the previously described total synthesis of this class of compounds and evaluated for biological activity. In general, there was a marked reduction in the relative binding affinities of these compounds for the rabbit uterus estrogen and progestin receptor proteins. None of the compounds which were subjected to uterotropic, antiuterotropic, postcoital, progestational, antiprogestational, or antiandrogenic assays showed any significant activity.Entities:
Keywords: Animals, Laboratory; Biology; Clinical Research; Contraception; Contraception Research; Endocrine System; Estrogens--analysis; Examinations And Diagnoses; Family Planning; Genitalia; Genitalia, Female; Hormone Receptors; Hormones; In Vitro; Laboratory Examinations And Diagnoses; Laboratory Procedures; Membrane Proteins; Physiology; Progestational Hormones; Progesterone--analysis; Research Methodology; Urogenital System; Uterus
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Year: 1977 PMID： 850240 DOI： 10.1021/jm00214a017
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446