| Literature DB >> 850236 |
J L Kelley, C A Miller, H L White.
Abstract
Twenty-eight derivatives of histidine were tested as inhibitors of histidine decarboxylase from rat stomach. Potent inhibition was observed with the methyl ester of L-histidine (1) which had a Ki = 1.8 X 10(-6) M. Substitution on 1 at various positions resulted in a decrease or complete loss of inhibition. Substituent requirements for inhibition of histidine decarboxylase are discussed. A simple disposable apparatus for the radiometric assay of histidine decarboxylase is described.Entities:
Mesh：
Substances：
Year: 1977 PMID： 850236 DOI： 10.1021/jm00214a009
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446