Literature DB >> 850133

Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response.

Y H Chang.   

Abstract

A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (el4 cells) in the arthritic rat. Application of the new model system to mechanism studies is illustrated with cyclophosphamide. The drug is shown to suppress adjuvant arthritis by a combined anti-inflammatory and immunosuppressive action.

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Year:  1977        PMID： 850133

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


  4 in total

1.  Haemorrhage produces depressions in alloantigen-specific immune responses in the mouse through activation of suppressor T cells.

Authors:  Y H Chang; M Jagels; E Abraham
Journal:  Clin Exp Immunol       Date:  1990-06       Impact factor: 4.330

Review 2.  Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs?

Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1982-10

3.  Altered susceptibility of arthritic rats to the gastric lesion-inducing effects of aspirin or ethanol and the antilesion effect of rioprostil.

Authors:  L B Katz; T Genna; B L Fuller; E L Tolman; D A Shriver
Journal:  Agents Actions       Date:  1987-10

4.  Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan.

Authors:  Y H Chang; C M Pearson; L Chedid
Journal:  J Exp Med       Date:  1981-04-01       Impact factor: 14.307
  4 in total

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