Literature DB >> 8500916

Production of interleukin-6 by human and murine mononuclear leukocytes stimulated with Plasmodium antigens is enhanced by pentoxifylline, and tumor necrosis factor secretion is reduced.

J Prada1, C Prager, S Neifer, U Bienzle, P G Kremsner.   

Abstract

When pentoxifylline was present during stimulation of human mononuclear leukocytes with Plasmodium falciparum exogenous antigens, an increase in interleukin-6 production was observed simultaneously with a reduction of tumor necrosis factor secretion. Similar results were obtained in murine macrophages stimulated with P. vinckei antigens. This indicates the independence of interleukin-6 and tumor necrosis factor secretion in response to malaria antigens.

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Year:  1993        PMID： 8500916      PMCID： PMC280911          DOI： 10.1128/iai.61.6.2737-2740.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

1.  Application of anti-TNF to Plasmodium vinckei-infected mice is followed by an increase of parasitaemia.

Authors:  S Neifer; P G Kremsner; U Bienzle
Journal:  Acta Trop       Date:  1989-07       Impact factor: 3.112

2.  Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline.

Authors:  R M Strieter; D G Remick; P A Ward; R N Spengler; J P Lynch; J Larrick; S L Kunkel
Journal:  Biochem Biophys Res Commun       Date:  1988-09-30       Impact factor: 3.575

3.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

4.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

5.  Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria.

Authors:  P Kern; C J Hemmer; J Van Damme; H J Gruss; M Dietrich
Journal:  Am J Med       Date:  1989-08       Impact factor: 4.965

6.  Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by monocytes and T cells.

Authors:  L Schandené; P Vandenbussche; A Crusiaux; M L Alègre; D Abramowicz; E Dupont; J Content; M Goldman
Journal:  Immunology       Date:  1992-05       Impact factor: 7.397

7.  Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.

Authors:  G E Grau; L F Fajardo; P F Piguet; B Allet; P H Lambert; P Vassalli
Journal:  Science       Date:  1987-09-04       Impact factor: 47.728

8.  Production of hybridoma growth factor by human monocytes.

Authors:  L A Aarden; E R De Groot; O L Schaap; P M Lansdorp
Journal:  Eur J Immunol       Date:  1987-10       Impact factor: 5.532

9.  Tumor necrosis factor and disease severity in children with falciparum malaria.

Authors:  G E Grau; T E Taylor; M E Molyneux; J J Wirima; P Vassalli; M Hommel; P H Lambert
Journal:  N Engl J Med       Date:  1989-06-15       Impact factor: 91.245

10.  Soluble malarial antigens are toxic and induce the production of tumour necrosis factor in vivo.

Authors:  C A Bate; J Taverne; J H Playfair
Journal:  Immunology       Date:  1989-04       Impact factor: 7.397
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  8 in total

1.  Pentoxifylline attenuates ischemia/reperfusion injury to the small intestine in the rat.

Authors:  R Udassin; A Vromen; D Seror; Y Haskel
Journal:  Pediatr Surg Int       Date:  2013-09-21       Impact factor: 1.827

2.  Pentoxifylline treatment of mice with chronic pulmonary tuberculosis accelerates the development of destructive pathology.

Authors:  J Turner; A A Frank; J V Brooks; P M Marietta; I M Orme
Journal:  Immunology       Date:  2001-02       Impact factor: 7.397

3.  Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response.

Authors:  W Rudin; H P Eugster; G Bordmann; J Bonato; M Müller; M Yamage; B Ryffel
Journal:  Am J Pathol       Date:  1997-01       Impact factor: 4.307

4.  Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea.

Authors:  Leanne J Robinson; Marthe C D'Ombrain; Danielle I Stanisic; Jack Taraika; Nicholas Bernard; Jack S Richards; James G Beeson; Livingstone Tavul; Pascal Michon; Ivo Mueller; Louis Schofield
Journal:  Infect Immun       Date:  2009-04-20       Impact factor: 3.441

5.  Influence of pentoxifylline and its derivatives on antibiotic uptake and superoxide generation by human phagocytic cells.

Authors:  W L Hand; D L Hand
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191

6.  Upregulation of ICAM-I by Plasmodium falciparum: in vitro and in vivo studies.

Authors:  W Graninger; J Prada; S Neifer; G Zotter; F Thalhammer; P G Kremsner
Journal:  J Clin Pathol       Date:  1994-07       Impact factor: 3.411

7.  Pentoxifylline as an adjunct therapy in children with cerebral malaria.

Authors:  Bertrand Lell; Carsten Köhler; Betty Wamola; Christopher Ho Olola; Esther Kivaya; Gilbert Kokwaro; David Wypij; Sadik Mithwani; Terrie E Taylor; Peter G Kremsner; Charles R J C Newton
Journal:  Malar J       Date:  2010-12-21       Impact factor: 2.979

Review 8.  Malarial pigment hemozoin and the innate inflammatory response.

Authors:  Martin Olivier; Kristin Van Den Ham; Marina Tiemi Shio; Fikregabrail Aberra Kassa; Sophie Fougeray
Journal:  Front Immunol       Date:  2014-02-05       Impact factor: 7.561
  8 in total

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