Literature DB >> 849986

Effect of methysergide and pimozide on apomorphine-induced growth hormone secretion in men.

S Lal, H Guyda, S Bikadoroff.   

Abstract

The dopamine receptor agonist, apomorphine HCl (0.75 mg sc) increased serum growth hormone (GH) concentrations in each of 6 subjects. This increase was not inhibited by pretreatment with the serotonin antagonist, methysergide, but was completely abolished in the 4 individuals pretreated with pimozide, a selective dopamine receptor blocking agent. These results provide further evidence that apomorphine-induced GH secretion is mediated by a dopaminergic mechanism and is independent of a serotonergic mechanism.

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Year:  1977        PMID： 849986     DOI： 10.1210/jcem-44-4-766

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  13 in total

Review 1.  Apomorphine and the dopamine hypothesis of schizophrenia: a dilemma?

Authors:  L Dépatie; S Lal
Journal:  J Psychiatry Neurosci       Date:  2001-05       Impact factor: 6.186

Review 2.  Some current aspects of clinical and experimental neuroendocrinology with particular reference to growth hormone, thyrotropin and prolactin.

Authors:  M F Scanlon; M Pourmand; A M McGregor; M D Rodriguez-Arnao; K Hall; A Gomez-Pan; R Hall
Journal:  J Endocrinol Invest       Date:  1979 Jul-Sep       Impact factor: 4.256

Review 3.  Neuroendocrine markers of CNS drug effects.

Authors:  E C Johnstone; I N Ferrier
Journal:  Br J Clin Pharmacol       Date:  1980-07       Impact factor: 4.335

4.  Hypothalamic-pituitary dopaminergic function in hepatic failure in man.

Authors:  S Lal; M Oravec; A Aronoff; M E Kiely; H Guyda; S Solomon; N P Nair
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

5.  The effect of Yohimbine, an alpha2 adrenergic receptor antagonist, on the growth hormone response to apomorphine in normal subjects.

Authors:  S Lal; J X Thavundayil; B Krishnan; N P Nair; G Schwartz; H Guyda
Journal:  J Psychiatry Neurosci       Date:  1996-03       Impact factor: 6.186

6.  Stereospecificity of the dopamine receptor mediating the growth hormone response to apomorphine in man. Short communication.

Authors:  S Lal; N P Nair; J X Thavundayil; V Tawar; R Quirion; H Guyda
Journal:  J Neural Transm Gen Sect       Date:  1991

7.  Effect of bromocriptine in patients with apomorphine-responsive erectile impotence: an open study.

Authors:  S Lal; M E Kiely; J X Thavundayil; J D Stewart; P Assalian; C F Ackman
Journal:  J Psychiatry Neurosci       Date:  1991-12       Impact factor: 6.186

8.  Effects of L-deprenyl on human growth hormone secretion.

Authors:  M Koulu; R Lammintausta
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575

9.  Effects of short-term administration of valproate on serotonin-1A and dopamine receptor function in healthy human subjects.

Authors:  Nicholas J Delva; Deborah L Brooks; Michael Franklin; Khalid al-Said; Emily R Hawken; Zul Merali; J Stuart Lawson; Arun V Ravindran
Journal:  J Psychiatry Neurosci       Date:  2002-11       Impact factor: 6.186

10.  Effect of domperidone on apomorphine-induced growth hormone secretion in normal men.

Authors:  S Lal; N P Nair; H L Iskandar; P Etienne; P L Wood; G Schwartz; H Guyda
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575
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