Literature DB >> 8499079

The roles of CD8 in cytotoxic T lymphocyte function.

A M O'Rourke1, M F Mescher.   

Abstract

The CD8 glycoprotein of cytotoxic T cells is both an adhesion protein and a cosignalling receptor. These functions are regulated by signals from the T-cell antigen receptor complex (TCR-CD3), and CD8 acts to couple TCR occupancy to second messenger pathways. Here Anne O'Rourke and Matthew Mescher examine the roles of CD8 in activating the adhesion and signalling cascade initiated by antigen binding.

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Year:  1993        PMID： 8499079     DOI： 10.1016/0167-5699(93)90283-q

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  17 in total

1.  A nonhuman primate model for the selective elimination of CD8+ lymphocytes using a mouse-human chimeric monoclonal antibody.

Authors:  J E Schmitz; M A Simon; M J Kuroda; M A Lifton; M W Ollert; C W Vogel; P Racz; K Tenner-Racz; B J Scallon; M Dalesandro; J Ghrayeb; E P Rieber; V G Sasseville; K A Reimann
Journal:  Am J Pathol       Date:  1999-06       Impact factor: 4.307

2.  Crystallization and preliminary X-ray crystallographic studies of swine CD8α.

Authors:  Nianzhi Zhang; Jianxun Qi; Xiaocheng Pan; ZhaoSan Chen; Xin Li; Feng Gao; Chun Xia
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-07-19

3.  Differential expression of MUC1 on transfected cell lines influences its recognition by MUC1 specific T cells.

Authors:  J Magarian-Blander; R P Hughey; C Kinlough; P A Poland; O J Finn
Journal:  Glycoconj J       Date:  1996-10       Impact factor: 2.916

4.  Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice.

Authors:  Matthew Marks; Tamika Burns; Maria Abadi; Beza Seyoum; Justin Thornton; Elaine Tuomanen; Liise-anne Pirofski
Journal:  Infect Immun       Date:  2007-02-12       Impact factor: 3.441

5.  Resting and activated T cells display different requirements for CD8 molecules.

Authors:  Z Cai; J Sprent
Journal:  J Exp Med       Date:  1994-06-01       Impact factor: 14.307

6.  AKR.H-2b lymphocytes inhibit the secondary in vitro cytotoxic T-lymphocyte response of primed responder cells to AKR/Gross murine leukemia virus-induced tumor cell stimulation.

Authors:  R F Rich; W R Green
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103

7.  Characterization of a novel monoclonal antibody against human perforin using transfected cell lines.

Authors:  B C Schlesinger; L Cheng
Journal:  Immunology       Date:  1994-02       Impact factor: 7.397

8.  Herpes simplex virus-specific human cytotoxic T-cell colonies expressing either gamma delta or alpha beta T-cell receptor: role of accessory molecules on HLA-unrestricted killing of virus-infected targets.

Authors:  R Maccario; P Comoli; E Percivalle; D Montagna; F Locatelli; G Gerna
Journal:  Immunology       Date:  1995-05       Impact factor: 7.397

9.  Requirements for peptide-induced T cell receptor downregulation on naive CD8+ T cells.

Authors:  Z Cai; H Kishimoto; A Brunmark; M R Jackson; P A Peterson; J Sprent
Journal:  J Exp Med       Date:  1997-02-17       Impact factor: 14.307

10.  Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts.

Authors:  S R Guehler; J A Bluestone; T A Barrett
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307
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