K J Moise1. 1. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.
Abstract
OBJECTIVE: The objective of this study was to determine whether indomethacin is associated with an increased incidence of constriction of the human fetal ductus arteriosus with advancing gestational age. STUDY DESIGN: A retrospective analysis of fetal echocardiograms performed in 44 patients with premature labor or hydramnios treated with indomethacin (25 mg orally every 6 hours) was undertaken. Fisher's exact test, Kaplan-Meier survival analysis, and log-rank techniques were used; a value of p < 0.05 was considered statistically significant. RESULTS: The frequency of ductal constriction was similar for fetuses of singleton and multiple gestations. A dramatic increase in constriction was noted at 32 weeks' gestation when the rate of compromise approached 50%. CONCLUSIONS: The use of indomethacin should be restricted to gestational ages of < 32 weeks. In multiple gestations each fetus should be evaluated by echocardiography, because the ductal response may vary between individual fetuses.
OBJECTIVE: The objective of this study was to determine whether indomethacin is associated with an increased incidence of constriction of the human fetal ductus arteriosus with advancing gestational age. STUDY DESIGN: A retrospective analysis of fetal echocardiograms performed in 44 patients with premature labor or hydramnios treated with indomethacin (25 mg orally every 6 hours) was undertaken. Fisher's exact test, Kaplan-Meier survival analysis, and log-rank techniques were used; a value of p < 0.05 was considered statistically significant. RESULTS: The frequency of ductal constriction was similar for fetuses of singleton and multiple gestations. A dramatic increase in constriction was noted at 32 weeks' gestation when the rate of compromise approached 50%. CONCLUSIONS: The use of indomethacin should be restricted to gestational ages of < 32 weeks. In multiple gestations each fetus should be evaluated by echocardiography, because the ductal response may vary between individual fetuses.
Authors: Melanie Vogel; Louise E Wilkins-Haug; Doff B McElhinney; Audrey C Marshall; Carol B Benson; Virginia Silva; Wayne Tworetzky Journal: Fetal Diagn Ther Date: 2009-12-17 Impact factor: 2.587
Authors: Afif El-Khuffash; Amish Jain; David Corcoran; Prakesh S Shah; Christopher W Hooper; Naoko Brown; Stanley D Poole; Elaine L Shelton; Ginger L Milne; Jeff Reese; Patrick J McNamara Journal: Pediatr Res Date: 2014-06-18 Impact factor: 3.756