Literature DB >> 8496955

Genetic evidence for the interaction between cluster I and cluster III rifampicin resistant mutations.

M Singer1, D J Jin, W A Walter, C A Gross.   

Abstract

Rifampicin-resistant (Rifr) mutations of Escherichia coli map to the central portion of the rpoB gene, which encodes the beta subunit of RNA polymerase. These mutations are located in three distinct clusters, designated I, II and III. Three intragenic suppressors of the cluster III Rifr mutation, rpoB3406(RH687), restore the ability of the mutant strain to grow at low and high temperatures and map to a single locus in cluster I. These suppressors are identical to two previously characterized Rifr alleles, rpoB3401(RC529) and rpoB3402(RS529). None of the other 14 previously identified Rifr mutations that we have characterized confers this phenotype. We suggest that this allele-specific suppression results from interaction between Cluster I and Cluster III of the beta subunit.

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Year:  1993        PMID： 8496955     DOI： 10.1006/jmbi.1993.1251

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  15 in total

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2.  Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus.

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3.  Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics.

Authors:  Ming Xu; Yan Ning Zhou; Beth P Goldstein; Ding Jun Jin
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4.  EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2).

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Review 5.  Structural perspective on mutations affecting the function of multisubunit RNA polymerases.

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6.  Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis.

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Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-13       Impact factor: 11.205

7.  Mapping the sigma70 subunit contact sites on Escherichia coli RNA polymerase with a sigma70-conjugated chemical protease.

Authors:  J T Owens; R Miyake; K Murakami; A J Chmura; N Fujita; A Ishihama; C F Meares
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8.  Competitive fitness during feast and famine: how SOS DNA polymerases influence physiology and evolution in Escherichia coli.

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Journal:  Genetics       Date:  2013-04-15       Impact factor: 4.562

9.  Molecular basis of rifampin resistance in Streptococcus pneumoniae.

Authors:  T Padayachee; K P Klugman
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191

10.  Characterization of mutations in the rpoB gene in naturally rifampin-resistant Rickettsia species.

Authors:  M Drancourt; D Raoult
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191
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