OBJECTIVE: To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA). METHODS: Open prospective study of 50 patients with RA treated with GSTM. Serum IL-6 measured by bioassay. RESULTS: IL-6 showed correlations with Ritchie articular index, duration of morning stiffness and C-reactive protein. GSTM significantly reduced IL-6 levels. CONCLUSIONS: IL-6 is a potentially useful additional indicator of disease activity in RA and is modulated by GSTM.
OBJECTIVE: To determine the clinical utility and the effect of sodium aurothiomalate (GSTM) on serum interleukin 6 (IL-6) levels in patients with rheumatoid arthritis (RA). METHODS: Open prospective study of 50 patients with RA treated with GSTM. Serum IL-6 measured by bioassay. RESULTS:IL-6 showed correlations with Ritchie articular index, duration of morning stiffness and C-reactive protein. GSTM significantly reduced IL-6 levels. CONCLUSIONS:IL-6 is a potentially useful additional indicator of disease activity in RA and is modulated by GSTM.
Authors: Widian K Jubair; Jason D Hendrickson; Erin L Severs; Hanna M Schulz; Sumitra Adhikari; Diana Ir; Jose D Pagan; Robert M Anthony; Charles E Robertson; Daniel N Frank; Nirmal K Banda; Kristine A Kuhn Journal: Arthritis Rheumatol Date: 2018-07-02 Impact factor: 10.995