Literature DB >> 8495732

Direct influence of morphine on the release of arachidonic acid and its metabolites.

M G Sergeeva1, I V Terentjeva, A T Mevkh, S D Varfolomeev.   

Abstract

The influence of 10(-10)-10(-6) M morphine on the release of [3H]arachidonic acid and its metabolites ([3H]AAM) from prelabeled resident peritoneal murine macrophages was investigated. Morphine enhanced [3H]AAM release from A23187- and LPS-stimulated macrophages, as well as the basal release of [3H]AAM. Dose-response curves showed a maximum at 10(-8) M morphine. Naloxone had no effect on morphine enhancement of [3H]AAM release. These results are in agreement with the hypothesis that [3H]AAM may be involved in the effects of morphine.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8495732     DOI： 10.1016/0014-5793(93)81471-b

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

Review 1.  Effects of opioids on the immune system.

Authors:  S Roy; H H Loh
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996

2.  Ultralow concentrations of ibuprofen activate cell prostaglandin synthesis.

Authors:  M G Sergeeva; M V Gonchar; V V Chistyakov; A T Mevkh
Journal:  Appl Biochem Biotechnol       Date:  1996 Oct-Nov       Impact factor: 2.926

3.  Peripheral administration of morphine attenuates postincisional pain by regulating macrophage polarization through COX-2-dependent pathway.

Authors:  Kohei Godai; Maiko Hasegawa-Moriyama; Tae Kurimoto; Takayuki Saito; Tomotsugu Yamada; Takahiro Sato; Masayasu Kojima; Yuichi Kanmura
Journal:  Mol Pain       Date:  2014-06-14       Impact factor: 3.395
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.