Literature DB >> 8495245

Adenosine A3 receptors mediate hypotension in the angiotensin II-supported circulation of the pithed rat.

J R Fozard1, A M Carruthers.   

Abstract

The cardiovascular effects of N6-2-(4-aminophenyl)ethyladenosine (APNEA), which when radiolabelled with 125I shows high affinity for the newly described adenosine A3 receptor, have been investigated in the angiotensin II-supported circulation of the pithed rat. APNEA induces hypotensive responses which are unaffected by high doses (20-40 mg kg-1) of the broad spectrum, adenosine receptor antagonist, 8-(p-sulphophenyl)theophylline (8-SPT). 8-SPT-resistant falls in blood pressure are also seen, in the absence of bradycardia, with 5'-N-ethylcarboxamidoadenosine (NECA) and the R- and S-enantiomers of N6-phenylisopropyladenosine (PIA). Xanthine insensitivity, high potencies of APNEA, NECA and R-PIA, and an enantiomeric selectivity favouring R- over S-PIA are distinguishing features of the adenosine A3 receptor. We suggest that hypotension in the pithed rat may be a functional correlate of this site.

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Year:  1993        PMID： 8495245      PMCID： PMC2175589          DOI： 10.1111/j.1476-5381.1993.tb13522.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

Review 1.  Structure and function of A1 adenosine receptors.

Authors:  J Linden
Journal:  FASEB J       Date:  1991-09       Impact factor: 5.191

Review 2.  Adenosine receptors and calcium: basis for proposing a third (A3) adenosine receptor.

Authors:  J A Ribeiro; A M Sebastião
Journal:  Prog Neurobiol       Date:  1986       Impact factor: 11.685

3.  Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

Authors:  R F Bruns; G H Lu; T A Pugsley
Journal:  Mol Pharmacol       Date:  1986-04       Impact factor: 4.436

4.  Cardiovascular effects of endothelin 1 in pithed spontaneously hypertensive rats: evaluation of its mechanism(s) of action.

Authors:  A K Mir; H Berthold; G E Scholtysik; J R Fozard
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

5.  Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

Authors:  Q Y Zhou; C Li; M E Olah; R A Johnson; G L Stiles; O Civelli
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

6.  CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.

Authors:  A J Hutchison; R L Webb; H H Oei; G R Ghai; M B Zimmerman; M Williams
Journal:  J Pharmacol Exp Ther       Date:  1989-10       Impact factor: 4.030
  6 in total
  31 in total

1.  Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release.

Authors:  C I Ezeamuzie; E Philips
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

2.  Analysis of the atypical characteristics of adenosine receptors mediating negative inotropic and chronotropic responses of guinea-pig isolated atria and papillary muscles.

Authors:  N M Gardner; K J Broadley
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

3.  The adenosine receptor agonist, APNEA, increases calcium influx into rat cortical synaptosomes through N-type channels associated with A2a receptors.

Authors:  S N Li; P T Wong
Journal:  Neurochem Res       Date:  2000-04       Impact factor: 3.996

4.  Tissue distribution of adenosine receptor mRNAs in the rat.

Authors:  A K Dixon; A K Gubitz; D J Sirinathsinghji; P J Richardson; T C Freeman
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

5.  Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats.

Authors:  E A Van Schaick; K A Jacobson; H O Kim; A P IJzerman; M Danhof
Journal:  Eur J Pharmacol       Date:  1996-07-25       Impact factor: 4.432

6.  Selective ligands for rat A3 adenosine receptors: structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives.

Authors:  H O Kim; X D Ji; N Melman; M E Olah; G L Stiles; K A Jacobson
Journal:  J Med Chem       Date:  1994-11-11       Impact factor: 7.446

7.  Adenosine receptors mediate both contractile and relaxant effects of adenosine in main pulmonary artery of guinea pigs.

Authors:  A J Szentmiklósi; A Ujfalusi; A Cseppentö; K Nosztray; P Kovács; J Z Szabó
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-04       Impact factor: 3.000

8.  Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo.

Authors:  R A Mathôt; E M Van der Wenden; W Soudijn; A P IJzerman; M Danhof
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

9.  125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.

Authors:  M E Olah; C Gallo-Rodriguez; K A Jacobson; G L Stiles
Journal:  Mol Pharmacol       Date:  1994-05       Impact factor: 4.436

10.  Molecular cloning and characterization of the human A3 adenosine receptor.

Authors:  C A Salvatore; M A Jacobson; H E Taylor; J Linden; R G Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205
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