Literature DB >> 8494646

Lithium treatment blocks long-term synaptic depression in the striatum.

P Calabresi1, A Pisani, N B Mercuri, G Bernardi.   

Abstract

We have studied the effect of acute and chronic lithium treatment on the activity of striatal neurons recorded from corticostriatal slices. Under control conditions, tetanic stimulation of glutamatergic corticostriatal terminals caused long-term depression (LTD) of excitatory synaptic potentials. Acute lithium treatment did not affect the peak of the induction phase, but it reduced the following phases of LTD. LTD was completely blocked in slices obtained from rats chronically injected with LiCl. Lithium treatment failed to affect the intrinsic membrane properties of striatal neurons and the presynaptic inhibitory effects of carbachol and t-ACPD. We suggest that the lithium-induced blockade of LTD may contribute to the therapeutic action of lithium salts in mania and depression.

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Year:  1993        PMID： 8494646     DOI： 10.1016/0896-6273(93)90210-i

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  8 in total

1.  Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors.

Authors:  P Calabresi; A Saiardi; A Pisani; J H Baik; D Centonze; N B Mercuri; G Bernardi; E Borrelli
Journal:  J Neurosci       Date:  1997-06-15       Impact factor: 6.167

2.  A critical role of the nitric oxide/cGMP pathway in corticostriatal long-term depression.

Authors:  P Calabresi; P Gubellini; D Centonze; G Sancesario; M Morello; M Giorgi; A Pisani; G Bernardi
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

3.  Case Studies in Neuroscience: Lack of inhibitory synaptic plasticity in the substantia nigra pars reticulata of a patient with lithium-induced tremor.

Authors:  Luka Milosevic; Robert F Dallapiazza; Renato P Munhoz; Suneil K Kalia; Milos R Popovic; William D Hutchison
Journal:  J Neurophysiol       Date:  2019-08-14       Impact factor: 2.714

4.  Glutamate-triggered events inducing corticostriatal long-term depression.

Authors:  P Calabresi; D Centonze; P Gubellini; G A Marfia; G Bernardi
Journal:  J Neurosci       Date:  1999-07-15       Impact factor: 6.167

5.  Neuroprotective effects of lithium treatment following hypoxic-ischemic brain injury in neonatal rats.

Authors:  Won-Jung Shin; Mijeung Gwak; Chong-Hwa Baek; Ki-Soo Kim; Pyung-Hwan Park
Journal:  Childs Nerv Syst       Date:  2011-11-18       Impact factor: 1.475

6.  Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine.

Authors:  P Calabresi; P Gubellini; B Picconi; D Centonze; A Pisani; P Bonsi; P Greengard; R A Hipskind; E Borrelli; G Bernardi
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

7.  A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders.

Authors:  Yanqiong Zhang; Xia Mao; Jing Su; Ya Geng; Rui Guo; Shihuan Tang; Junfang Li; Xuefeng Xiao; Haiyu Xu; Hongjun Yang
Journal:  Chin Med       Date:  2017-08-21       Impact factor: 5.455

8.  Dietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Shank3 Exon 13-16 Mutant Mice.

Authors:  Chantelle Fourie; Yukti Vyas; Kevin Lee; Yewon Jung; Craig C Garner; Johanna M Montgomery
Journal:  Front Cell Neurosci       Date:  2018-10-22       Impact factor: 5.505
  8 in total

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