Literature DB >> 8494394

In vitro activity of cycloguanil against African isolates of Plasmodium falciparum.

L K Basco1, O Ramiliarisoa, P Ringwald, J C Doury, J Le Bras.   

Abstract

The in vitro activity of cycloguanil was assessed against 86 African isolates of Plasmodium falciparum by a semi-micro assay system. A bimodal distribution of susceptibility patterns was observed, with 44% of the isolates being cycloguanil susceptible. Cycloguanil alone retains a high activity against the intraerythrocytic forms of some isolates and, together with its activity against the hepatic stages, may be useful for chemoprophylaxis when combined with chloroquine.

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Year:  1993        PMID： 8494394      PMCID： PMC187818          DOI： 10.1128/AAC.37.4.924

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil.

Authors:  E Petersen; B Hogh; A P Hanson; A Bjorkman; H Flacks
Journal:  Ann Trop Med Parasitol       Date:  1990-12

2.  A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii.

Authors:  R E Howells; H M Gilles; N S Bent
Journal:  Ann Trop Med Parasitol       Date:  1985-06

3.  In vitro susceptibility of Plasmodium falciparum isolates from Jilore, Kenya, to antimalarial drugs.

Authors:  W M Watkins; R E Howells; A D Brandling-Bennett; D K Koech
Journal:  Am J Trop Med Hyg       Date:  1987-11       Impact factor: 2.345

4.  Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.

Authors:  D S Peterson; W K Milhous; T E Wellems
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

5.  Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.

Authors:  S J Foote; D Galatis; A F Cowman
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

6.  Prolonged malaria prophylaxis with chloroquine and proguanil (chloroguanide) in a nonimmune resident population of an endemic area with a high prevalence of chloroquine resistance.

Authors:  D Gozal; C Hengy; G Fadat
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

7.  The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.

Authors:  W M Watkins; D G Sixsmith; J D Chulay
Journal:  Ann Trop Med Parasitol       Date:  1984-06

8.  Activity of dihydrofolate reductase inhibitors on the hepatic stages of Plasmodium yoelii yoelii in vitro.

Authors:  B Eriksson; B Courtier; A Bjŏrkman; F Miltgen; D Mazier
Journal:  Trans R Soc Trop Med Hyg       Date:  1991 Nov-Dec       Impact factor: 2.184

9.  In vitro activity of antimalarial compounds on the exoerythrocytic stages of Plasmodium cynomolgi and P. knowlesi.

Authors:  T L Fisk; P Millet; W E Collins; P Nguyen-Dinh
Journal:  Am J Trop Med Hyg       Date:  1989-03       Impact factor: 2.345

10.  In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-micro test.

Authors:  J Le Bras; P Deloron
Journal:  Am J Trop Med Hyg       Date:  1983-05       Impact factor: 2.345
  10 in total
  1 in total

1.  Adaptation of the [3H]Hypoxanthine Uptake Assay for In Vitro-Cultured Plasmodium knowlesi Malaria Parasites.

Authors:  Megan S J Arnold; Jessica A Engel; Ming Jang Chua; Gillian M Fisher; Tina S Skinner-Adams; Katherine T Andrews
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191
  1 in total

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