Literature DB >> 8493557

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.

L F Lin1, D H Doherty, J D Lile, S Bektesh, F Collins.   

Abstract

A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. These effects were relatively specific; GDNF did not increase total neuron or astrocyte numbers nor did it increase transmitter uptake by gamma-aminobutyric-containing and serotonergic neurons. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.

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Year:  1993        PMID： 8493557     DOI： 10.1126/science.8493557

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  706 in total

1.  Expression of GDNF and GDNFR-alpha mRNAs in muscles of patients with motor neuron diseases.

Authors:  M Yamamoto; N Mitsuma; A Inukai; Y Ito; M Li; T Mitsuma; G Sobue
Journal:  Neurochem Res       Date:  1999-06       Impact factor: 3.996

Review 2.  Molecular mechanisms regulating motor neuron development and degeneration.

Authors:  T J Kilpatrick; M Soilu-Hänninen
Journal:  Mol Neurobiol       Date:  1999-06       Impact factor: 5.590

3.  Role for GDNF in biochemical and behavioral adaptations to drugs of abuse.

Authors:  C J Messer; A J Eisch; W A Carlezon; K Whisler; L Shen; D H Wolf; H Westphal; F Collins; D S Russell; E J Nestler
Journal:  Neuron       Date:  2000-04       Impact factor: 17.173

Review 4.  Peripheral nerve regeneration and neurotrophic factors.

Authors:  G Terenghi
Journal:  J Anat       Date:  1999-01       Impact factor: 2.610

5.  Functional regeneration in a rat Parkinson's model after intrastriatal grafts of glial cell line-derived neurotrophic factor and transforming growth factor beta1-expressing extra-adrenal chromaffin cells of the Zuckerkandl's organ.

Authors:  E F Espejo; M C Gonzalez-Albo; J P Moraes; F El Banoua; J A Flores; I Caraballo
Journal:  J Neurosci       Date:  2001-12-15       Impact factor: 6.167

Review 6.  Regulation of neurotrophin signaling in aging sensory and motoneurons: dissipation of target support?

Authors:  B Ulfhake; E Bergman; E Edstrom; B T Fundin; H Johnson; S Kullberg; Y Ming
Journal:  Mol Neurobiol       Date:  2000-06       Impact factor: 5.590

7.  Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers.

Authors:  S J Newfeld; R G Wisotzkey; S Kumar
Journal:  Genetics       Date:  1999-06       Impact factor: 4.562

8.  An immortalized, type-1 astrocyte of mesencephalic origin source of a dopaminergic neurotrophic factor.

Authors:  D M Panchision; P A Martin-DeLeon; T Takeshima; J M Johnston; K Shimoda; P Tsoulfas; R D McKay; J W Commissiong
Journal:  J Mol Neurosci       Date:  1998-12       Impact factor: 3.444

9.  Early and late molecular events in neurodegeneration and neuroprotection in Parkinson's disease MPTP model as assessed by cDNA microarray; the role of iron.

Authors:  Moussa B.H. Youdim; Edna Grünblatt; Yona Levites; Gila Maor; Silvia Mandel
Journal:  Neurotox Res       Date:  2002 Nov-Dec       Impact factor: 3.911

10.  Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray.

Authors:  Silvia Mandel; Edna Grünblatt; Gila Maor; Moussa B H Youdim
Journal:  Neurochem Res       Date:  2002-10       Impact factor: 3.996
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