Literature DB >> 8493449

Effects of androgens on proliferation and progesterone receptor levels in T47D human breast cancer cells.

M H Liberato1, S Sonohara, M M Brentani.   

Abstract

The effects of estradiol (E2), dihydrotestosterone (DHT) and dehydro-3-epiandrosterone (DHEA) on proliferation and progesterone receptor induction were studied in a breast cancer cell line (T47D) expressing estrogen, androgen, and progesterone receptors. A significant enhancement of growth and progesterone receptor expression was observed after treatment with E2 and DHEA, which was antagonized by the antiestrogen tamoxifen and not altered by the antiandrogen flutamide, supporting the involvement of estrogen receptors. When cells were treated with either E2 or DHEA, transforming growth factor-alpha mRNA was induced. DHT treatment did not alter growth but was effective in stimulating androgen receptors and down-regulating progesterone receptors.

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Year:  1993        PMID： 8493449     DOI： 10.1159/000217823

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  6 in total

1.  Androgen receptor expression in ductal carcinoma in situ of the breast: relation to oestrogen and progesterone receptors.

Authors:  A G A Selim; G El-Ayat; C A Wells
Journal:  J Clin Pathol       Date:  2002-01       Impact factor: 3.411

Review 2.  Dehydroepiandrosterone and diseases of aging.

Authors:  R R Watson; A Huls; M Araghinikuam; S Chung
Journal:  Drugs Aging       Date:  1996-10       Impact factor: 3.923

Review 3.  Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.

Authors:  Elisabet Stener-Victorin; Vasantha Padmanabhan; Kirsty A Walters; Rebecca E Campbell; Anna Benrick; Paolo Giacobini; Daniel A Dumesic; David H Abbott
Journal:  Endocr Rev       Date:  2020-07-01       Impact factor: 19.871

4.  Immunohistochemical localisation of androgen receptor in apocrine metaplasia and apocrine adenosis of the breast: relation to oestrogen and progesterone receptors.

Authors:  A G Selim; C A Wells
Journal:  J Clin Pathol       Date:  1999-11       Impact factor: 3.411

5.  Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis.

Authors:  Samir N Babayev; Chan Woo Park; Patrick W Keller; Bruce R Carr; Ruth A Word; Orhan Bukulmez
Journal:  Reprod Sci       Date:  2017-02-12       Impact factor: 3.060

6.  Cyclin A1 modulates the expression of vascular endothelial growth factor and promotes hormone-dependent growth and angiogenesis of breast cancer.

Authors:  Azharuddin Sajid Syed Khaja; Nishtman Dizeyi; Pradeep Kumar Kopparapu; Lola Anagnostaki; Pirkko Härkönen; Jenny Liao Persson
Journal:  PLoS One       Date:  2013-08-08       Impact factor: 3.240
  6 in total

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