MIRD formulation.

The MIRD scheme is not restricted to calculating mean absorbed doses in organs but can be extended to any tissue for which distribution and retention data can be obtained and for which a reasonably accurate mathematical description of the source and target tissues can be determined. The development of more accurate absorbed dose estimates and the correlation of these estimates with radiation effects will lead to a better understanding of the results from radiotherapeutic agents such as radiolabeled monoclonal antibodies. Therefore, radiobiologists and internal dosimetrists need to combine their efforts and work toward the common goal of improving the treatment of malignant diseases.