Literature DB >> 849250

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. VI. Enzymatic studies of two mutants unable to convert inosinic acid to adenylic acid.

A S Tu, D Patterson.   

Abstract

Ade-H and ade-I are two auxotrophic mutants of Chinese hamster ovary (CHO-K1) cells which specifically require adenine as the purine source to grow. The enzymatic defects of these mutants were examined in cell-free extracts. It was found that ade-H did not have any detectable adenylosuccinate synthetase activity and ade-I was defective in the adenylosuccinate lyase enzyme. The relevance of adenine-requiring mutants to the study of the regulation of purine metabolism in mammalian cells is discussed.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 849250     DOI： 10.1007/BF00484561

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  19 in total

1.  THE ENZYMOLOGY OF FEEDBACK INHIBITION OF GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE BY PURINE RIBONUCLEOTIDES.

Authors:  C T CASKEY; D M ASHTON; J B WYNGAARDEN
Journal:  J Biol Chem       Date:  1964-08       Impact factor: 5.157

2.  The mechanism of action of hadacidin.

Authors:  H T SHIGEURA; C N GORDON
Journal:  J Biol Chem       Date:  1962-06       Impact factor: 5.157

3.  Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells.

Authors:  L A Chasin
Journal:  Cell       Date:  1974-05       Impact factor: 41.582

4.  Repression and derepression of purine biosynthesis in mammalian hepatoma cells in culture.

Authors:  D W Martin; N T Owen
Journal:  J Biol Chem       Date:  1972-09-10       Impact factor: 5.157

5.  A kinetic analysis of purine nucleotide synthesis and interconversion in intact Ehrlich ascites tumor cells.

Authors:  F F Snyder; J F Henderson
Journal:  J Cell Physiol       Date:  1973-12       Impact factor: 6.384

6.  The mechanism of amino acid control of guanylate and adenylate biosynthesis.

Authors:  J Gallant; J Irr; M Cashel
Journal:  J Biol Chem       Date:  1971-09-25       Impact factor: 5.157

7.  Purine-excreting mutants of Saccharomyces cerevisiae. I. Isolation and genetic analysis.

Authors:  S Armitt; R A Woods
Journal:  Genet Res       Date:  1970-02       Impact factor: 1.588

8.  Control by feedback repression of the enzymes of purine biosynthesis in Aerobacter aerogenes.

Authors:  D P Nierlich; B Magasanik
Journal:  Biochim Biophys Acta       Date:  1971-02-23

9.  Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: biochemical analysis of eight mutants.

Authors:  D Patterson
Journal:  Somatic Cell Genet       Date:  1975-01

10.  Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. IV. Isolation of a mutant which accumulates adenylosuccinic acid and succinylaminoimidazole carboxamide ribotide.

Authors:  D Patterson
Journal:  Somatic Cell Genet       Date:  1976-05
View more
  6 in total

1.  Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: a cellular model of adenylosuccinate lyase deficiency.

Authors:  Lydia K Vliet; Terry G Wilkinson; Nathan Duval; Guido Vacano; Christine Graham; Marie Zikánová; Vaclava Skopova; Veronika Baresova; Aleš Hnízda; Stanislav Kmoch; David Patterson
Journal:  Mol Genet Metab       Date:  2010-09-06       Impact factor: 4.797

2.  Molecular characterization of a patient with del(1)(q23-q25).

Authors:  B Franco; L W Lai; D Patterson; D H Ledbetter; B J Trask; G van den Engh; S Iannaccone; S Frances; P I Patel; J R Lupski
Journal:  Hum Genet       Date:  1991-07       Impact factor: 4.132

3.  Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction.

Authors:  J L Swain; J J Hines; R L Sabina; O L Harbury; E W Holmes
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

4.  Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders.

Authors:  Nathan Duval; Kyleen Luhrs; Terry G Wilkinson; Veronika Baresova; Vaclava Skopova; Stanislav Kmoch; Guido N Vacano; Marie Zikanova; David Patterson
Journal:  Mol Genet Metab       Date:  2013-01-12       Impact factor: 4.797

5.  Residual adenylosuccinase activities in fibroblasts of adenylosuccinase-deficient children: parallel deficiency with adenylosuccinate and succinyl-AICAR in profoundly retarded patients and non-parallel deficiency in a mildly retarded girl.

Authors:  F Van den Bergh; M F Vincent; J Jaeken; G Van den Berghe
Journal:  J Inherit Metab Dis       Date:  1993       Impact factor: 4.982

6.  Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity.

Authors:  Randall C Mazzarino; Veronika Baresova; Marie Zikánová; Nathan Duval; Terry G Wilkinson; David Patterson; Guido N Vacano
Journal:  PLoS One       Date:  2021-07-20       Impact factor: 3.240
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.