| Literature DB >> 849246 |
Abstract
The need for proteins to maintain particular quarternary structures constrains variability in amino acid sequence. Monomeric enzymes are then expected to be more variable than dimeric forms, which in turn are expected to be more variable than tetrameric forms. These predictions are confirmed by analysis of available data on enzyme variation. Theories relating enzyme heterozygosity to metabolic function are discussed in the light of these findings.Mesh:
Substances:
Year: 1977 PMID: 849246 DOI: 10.1007/BF00484555
Source DB: PubMed Journal: Biochem Genet ISSN: 0006-2928 Impact factor: 1.890