| Literature DB >> 8491222 |
C Cotsyfakis1, A D Varvarigou, M Papadopoulos, S Stathaki, C I Stassinopoulou, E Chiotellis.
Abstract
In the present work a series of NxS2 ligands were synthesized, investigated for the formation of cationic, indium chelates and evaluated comparatively in experimental animals. The compounds under study formed indium complexes which were stable in vitro and presented myocardial uptake. Animal studies showed that the chemical structure of the ligand plays an important role in biodistribution. A system of one six-membered and two five-membered rings, formed by the metal and the donor atoms of the ligand, may constitute a basic structure for the development of new indium tracers with myocardial affinity.Entities:
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Year: 1993 PMID： 8491222 DOI： 10.1007/BF00169805
Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997