| Literature DB >> 8489494 |
T Eichholtz1, K Jalink, I Fahrenfort, W H Moolenaar.
Abstract
Lysophosphatidic acid (LPA) is a water-soluble phospholipid with hormone-like and growth-factor-like activities. LPA activates a putative G-protein-coupled receptor in responsive cells, but the natural source of exogenous LPA is unknown. Here we show that LPA is present in mammalian serum in an active form (bound to albumin) at concentrations of 1-5 microM, but is not detectable in platelet-poor plasma, suggesting that LPA is produced during blood clotting. We find that thrombin activation of platelets prelabelled with [32P]Pi results in the rapid release of newly formed [32P]LPA into the extracellular environment. We conclude that LPA is a novel platelet-derived lipid mediator that may play a role in inflammatory and proliferative responses to injury.Entities:
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Year: 1993 PMID： 8489494 PMCID： PMC1132420 DOI： 10.1042/bj2910677
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857