Literature DB >> 8488089

Contractile response of normotensive rat aorta to serum from salt-loaded Sprague-Dawley rats.

O A Sofola1, P C Obiefuna, B J Adegunloye.   

Abstract

Sprague-Dawley rats were made hypertensive by 6-week dietary salt loading with 8% NaCl in the diet and compared with control rats which had normal feed and water. At the end of this period, the salt-loaded group developed hypertension but the heart rate did not differ significantly from control. Serum taken from salt-loaded rats showed enhanced vasoconstrictor effect on normal rat's aorta when compared with controls. This enhanced vasoconstrictor effect was attenuated by adrenergic receptor blockers but not by serotoninergic blockers. Thus salt loading may induce accumulation of vasoactive agents in the blood of rats.

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Year:  1993        PMID： 8488089     DOI： 10.1007/bf00374976

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  10 in total

Review 1.  Parathyroid glands and cardiovascular functions.

Authors:  P K Pang; R Z Lewanczuk; C G Benishin
Journal:  Contrib Nephrol       Date:  1991       Impact factor: 1.580

2.  Altered responses of aortic smooth muscle from Sprague-Dawley rats with salt-induced hypertension.

Authors:  P C Obiefuna; A B Ebeigbe; O A Sofola; C P Aloamaka
Journal:  Clin Exp Pharmacol Physiol       Date:  1991-12       Impact factor: 2.557

3.  Plasma norepinephrine variations with dietary sodium intake.

Authors:  M G Nicholls; W Kiowski; A J Zweifler; S Julius; M A Schork; J Greenhouse
Journal:  Hypertension       Date:  1980 Jan-Feb       Impact factor: 10.190

4.  Mobilization of stored calcium for phasic contraction induced by norepinephrine in rabbit aorta.

Authors:  H Karaki; H Kubota; N Urakawa
Journal:  Eur J Pharmacol       Date:  1979-06-15       Impact factor: 4.432

Review 5.  Salt and hypertension: recent advances and perspectives.

Authors:  F C Luft
Journal:  J Lab Clin Med       Date:  1989-09

Review 6.  How does salt raise blood pressure? A hypothesis.

Authors:  H Gavras
Journal:  Hypertension       Date:  1986-01       Impact factor: 10.190

7.  Circulating catecholamine levels in human and experimental hypertension.

Authors:  J de Champlain; L Farley; D Cousineau; M R van Ameringen
Journal:  Circ Res       Date:  1976-02       Impact factor: 17.367

8.  Sensitization of aortic baroreceptors by high salt diet in Dahl salt-resistant rats.

Authors:  A U Ferrari; A L Mark
Journal:  Hypertension       Date:  1987-07       Impact factor: 10.190

9.  The vascular sensitizing character of plasma from spontaneously hypertensive rats.

Authors:  G L Wright
Journal:  Can J Physiol Pharmacol       Date:  1981-11       Impact factor: 2.273

10.  Dietary salt loading produces baroreflex impairment and mild hypertension in rats.

Authors:  E Miyajima; R D Buñag
Journal:  Am J Physiol       Date:  1985-08
  10 in total
  1 in total

1.  The mechanism of acidic pH-induced contraction in aortae from SHR and WKY rats enhanced by increasing blood pressure.

Authors:  K Furukawa; J Komaba; H Sakai; Y Ohizumi
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739
  1 in total

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