Literature DB >> 8487765

[In vitro suppression of translation of tick-borne encephalitis virus RNA using antisense nucleotides].

N Iu Nomokonova, V V Gorn, V V Vlasov.   

Abstract

Effect of antisense oligodeoxyribonucleotides on in vitro translation of RNAs corresponding to fragments of the tick-borne encephalitis virus genome has been investigated. Sequences optimal for oligonucleotide binding and translation arrest have been identified. The most efficient oligonucleotide (17-mer) at a concentration of 2.5 microM completely arrests translation of the RNA coding for the NS3 protein.

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Year:  1993        PMID: 8487765

Source DB:  PubMed          Journal:  Mol Biol (Mosk)        ISSN: 0026-8984


  1 in total

1.  Dipentafluorophenyl carbonate--a reagent for the synthesis of oligonucleotides and their conjugates.

Authors:  V A Efimov; A L Kalinkina; O G Chakhmakhcheva
Journal:  Nucleic Acids Res       Date:  1993-11-25       Impact factor: 16.971

  1 in total

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