| Literature DB >> 8486955 |
M J Alfa1, N Olson, P Degagne, F Plummer, W Namaara, I Maclean, A R Ronald.
Abstract
The humoral immune response to purified lipooligosaccharide (LOS) and outer membrane proteins (OMP) of Haemophilus ducreyi was evaluated. Sera from chancroid-endemic (Uganda, Kenya) and -nonendemic (Canada) countries were tested by an ELISA. The response to OMPs was cross-reactive with other Haemophilus species, and elevated levels of antibody were detected in patients that did not have chancroid. The LOS component stimulated an H. ducreyi-specific immune response that was detected only in patients with chancroid. The sensitivity of the LOS ELISA was 96% (95% confidence interval, 89.9%-100%) and the specificity was 97% (95% confidence interval, 95.8%-98.2%). Thus, the anti-H. ducreyi LOS immune response is a significant diagnostic and epidemiologic indicator.Entities:
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Year: 1993 PMID： 8486955 DOI： 10.1093/infdis/167.5.1206
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226