OBJECTIVE: To evaluate prospectively the effects of high-dose, short-term treatment with a glucocorticoid in an attempt to normalize ovarian failure and induce pregnancy in women presenting with infertility. DESIGN: Uncontrolled, nonrandomized prospective study. SETTING: Two university-based reproductive endocrinology clinics. PATIENTS: Eleven consecutive women with premature ovarian failure (POF) who were desirous of pregnancy. INTERVENTIONS: Prednisone 25 mg four times per day for 2 weeks. MAIN OUTCOME MEASURES: Two women demonstrated normalization of their serum gonadotropins, an increase of serum E2, and ultrasonographic visualization of follicular growth, with both conceiving. The other nine demonstrated no biochemical or clinical response. CONCLUSIONS: Premature ovarian failure may not be an irreversible process and may either spontaneously resolve or may respond to therapeutic modalities such as high-dose glucocorticoids in selected patients. In this uncontrolled study, the results were best with women with concomitant autoimmune thyroid disease and POF of < 2 years' duration.
OBJECTIVE: To evaluate prospectively the effects of high-dose, short-term treatment with a glucocorticoid in an attempt to normalize ovarian failure and induce pregnancy in women presenting with infertility. DESIGN: Uncontrolled, nonrandomized prospective study. SETTING: Two university-based reproductive endocrinology clinics. PATIENTS: Eleven consecutive women with premature ovarian failure (POF) who were desirous of pregnancy. INTERVENTIONS:Prednisone 25 mg four times per day for 2 weeks. MAIN OUTCOME MEASURES: Two women demonstrated normalization of their serum gonadotropins, an increase of serum E2, and ultrasonographic visualization of follicular growth, with both conceiving. The other nine demonstrated no biochemical or clinical response. CONCLUSIONS:Premature ovarian failure may not be an irreversible process and may either spontaneously resolve or may respond to therapeutic modalities such as high-dose glucocorticoids in selected patients. In this uncontrolled study, the results were best with women with concomitant autoimmune thyroid disease and POF of < 2 years' duration.
Authors: Seby L Edassery; Seerin V Shatavi; Jeremy P Kunkel; Charles Hauer; Cosima Brucker; Krishna Penumatsa; Yi Yu; James A Dias; Judith L Luborsky Journal: Fertil Steril Date: 2010-06-01 Impact factor: 7.329
Authors: Bryce D Warren; William K Kinsey; Lynda K McGinnis; Lane K Christenson; Susmita Jasti; Anne M Stevens; Brian K Petroff; Margaret G Petroff Journal: Cell Mol Immunol Date: 2014-10-20 Impact factor: 11.530