Literature DB >> 8485578

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors.

G Bajocchi1, S H Feldman, R G Crystal, A Mastrangeli.   

Abstract

To evaluate the potential for adenovirus-mediated central nervous system (CNS) gene transfer, the replication deficient recombinant adenovirus vectors Ad.RSV beta gal (coding for beta-galactosidase) and Ad-alpha 1AT (coding for human alpha 1-antitrypsin) were administered to the lateral ventricle of rats. Ad.RSV beta gal transferred beta-galactosidase to ependymal cells lining the ventricles whereas Ad-alpha 1AT mediated alpha 1-antitrypsin secretion into the cerebral spinal fluid for 1 week. These observations, together with beta-galactosidase activity in the globus pallidus and substantia nigra following stereotactic administration of Ad.RSV beta gal to the globus pallidus, suggest that adenovirus vectors will be useful for CNS gene therapy.

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Year:  1993        PMID： 8485578     DOI： 10.1038/ng0393-229

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  39 in total

1.  Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system.

Authors:  M Glatzel; E Flechsig; B Navarro; M A Klein; J C Paterna; H Büeler; A Aguzzi
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

2.  Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector.

Authors:  M A Passini; J H Wolfe
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

3.  Adenovirus vector-directed expression of the neurotrophin-3 receptor (TrkC) in mouse astrocytes.

Authors:  N Rubio; J Abad-Rodriguez
Journal:  J Neurovirol       Date:  2001-02       Impact factor: 2.643

Review 4.  Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.

Authors:  Pedro R Lowenstein; Donata Suwelack; Jinwei Hu; Xianpeng Yuan; Maximiliano Jimenez-Dalmaroni; Shyam Goverdhana; Maria G Castro
Journal:  Int Rev Neurobiol       Date:  2003       Impact factor: 3.230

5.  Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid.

Authors:  Ana Maria Gonzalez; Wendy Leadbeater; Sonia Podvin; Alexandra Borboa; Michael Burg; Ritsuko Sawada; James Rayner; Karen Sims; Tetsuya Terasaki; Conrad Johanson; Edward Stopa; Brian Eliceiri; Andrew Baird
Journal:  Brain Res       Date:  2010-08-21       Impact factor: 3.252

6.  Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivo.

Authors:  A J Holtmaat; W T Hermens; M A Sonnemans; R J Giger; F W Van Leeuwen; M G Kaplitt; A B Oestreicher; W H Gispen; J Verhaagen
Journal:  J Neurosci       Date:  1997-09-01       Impact factor: 6.167

7.  In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system.

Authors:  E M Torres; C Monville; P R Lowenstein; M G Castro; S B Dunnett
Journal:  Brain Res Mol Brain Res       Date:  2005-04-18

8.  Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.

Authors:  Marie Carlén; Konstantinos Meletis; Christian Göritz; Vladimer Darsalia; Emma Evergren; Kenji Tanigaki; Mario Amendola; Fanie Barnabé-Heider; Maggie S Y Yeung; Luigi Naldini; Tasuku Honjo; Zaal Kokaia; Oleg Shupliakov; Robert M Cassidy; Olle Lindvall; Jonas Frisén
Journal:  Nat Neurosci       Date:  2009-02-22       Impact factor: 24.884

9.  Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

Authors:  M Korte; O Griesbeck; C Gravel; P Carroll; V Staiger; H Thoenen; T Bonhoeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

10.  Retroviral-mediated gene transfer corrects very-long-chain fatty acid metabolism in adrenoleukodystrophy fibroblasts.

Authors:  N Cartier; J Lopez; P Moullier; F Rocchiccioli; M O Rolland; P Jorge; J Mosser; J L Mandel; P F Bougnères; O Danos
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205
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