Substrate delivery as a determinant of hepatic apoB secretion.

The evidence that apoB particles secreted by the liver can differ in number and composition has been reviewed. No evidence has yet emerged that changes in apoB100 itself affect the rate of its secretion from the liver. The metabolic role of apoB appears to be the prevention of lipid accumulation within the liver cell: when delivery of lipid to the liver increases, apoB secretion will increase pari passu. This reality in no way detracts from the critical role played by the LDL receptor in determining the number of LDL particles in plasma, nor does it diminish the potential importance of intracellular processes such as 7 alpha-hydroxylase activity to also mediate LDL receptor activity. However, it should be obvious that variation in catabolism by itself cannot explain all that has been observed in physiological and pathological studies. On the contrary, the whole process must be taken into account--the rate at which apoB particles are added to the circulation, the rate at which they are converted to LDL, and the rate at which they are irreversibly removed from plasma--if we are to understand and appreciate this most peculiar and most important of transport systems.