Literature DB >> 8482517

Duration-dependent attenuation of acetylcholine--but not histamine--induced relaxation of the aorta in diabetes mellitus.

N N Orie1, C P Aloamaka, V I Iyawe.   

Abstract

1. The relaxations of aortic preparations from 1, 4 and 12 week diabetic rats to acetylcholine and histamine were studied. 2. The relaxation to acetylcholine but not to histamine was significantly attenuated in the 4th and 12th weeks of the disease. In addition, the tissues became less sensitive to acetylcholine but not to histamine with increasing duration of the disease. 3. The results show that there is differential alteration in the responsiveness of the aorta from diabetic rats to both agents.

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Year:  1993        PMID： 8482517     DOI： 10.1016/0306-3623(93)90311-k

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  3 in total

1.  Increased nitric oxide activity compensates for increased oxidative stress to maintain endothelial function in rat aorta in early type 1 diabetes.

Authors:  A Joshi; O L Woodman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2012-09-11       Impact factor: 3.000

2.  Contribution of nitric oxide produced by inducible nitric oxide synthase to vascular responses of mesenteric arterioles in streptozotocin-diabetic rats.

Authors:  Tomohisa Ishikawa; Fumika Kohno; Ryosuke Kawase; Yuri Yamamoto; Koichi Nakayama
Journal:  Br J Pharmacol       Date:  2004-01-05       Impact factor: 8.739

3.  6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation.

Authors:  Salah A Ghareib; Hany M El-Bassossy; Ahmed A Elberry; Ahmad Azhar; Malcolm L Watson; Zainy Mohammed Banjar
Journal:  Drug Des Devel Ther       Date:  2015-11-09       Impact factor: 4.162
  3 in total

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