Literature DB >> 8482382

Endothelin-1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase. Evidence for involvement in stimulation of mitogenesis.

L C Wilkes1, V Patel, J R Purkiss, M R Boarder.   

Abstract

The mechanism whereby endothelin stimulates mitogenesis of vascular smooth muscle cells is not understood. Here we show that endothelin-1 stimulates phospholipase D by a protein kinase C and tyrosine kinase dependent mechanism, and present evidence that implicate the phosphatidic acid formed by phospholipase D in the mitogenic response.

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Year:  1993        PMID： 8482382     DOI： 10.1016/0014-5793(93)81556-f

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

Review 1.  The role of tyrosine phosphorylation in angiotensin II mediated intracellular signaling and cell growth.

Authors:  B Schieffer; K E Bernstein; M B Marrero
Journal:  J Mol Med (Berl)       Date:  1996-02       Impact factor: 4.599

2.  Inhibition of endothelin- and phorbol ester-stimulated tyrosine kinase activity by corticotrophin in the rat adrenal zona glomerulosa.

Authors:  S Kapas; J P Hinson
Journal:  Biochem J       Date:  1996-02-01       Impact factor: 3.857

Review 3.  Tyrosine kinase-mediated signal transduction pathways and the actions of polypeptide growth factors and G-protein-coupled agonists in smooth muscle.

Authors:  M D Hollenberg
Journal:  Mol Cell Biochem       Date:  1995 Aug-Sep       Impact factor: 3.396

4.  Stimulation of two vascular smooth muscle-derived cell lines by angiotensin II: differential second messenger responses leading to mitogenesis.

Authors:  C Morton; R Baines; I Masood; L Ng; M R Boarder
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

5.  The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts.

Authors:  C P Briscoe; A Martin; M Cross; M J Wakelam
Journal:  Biochem J       Date:  1995-02-15       Impact factor: 3.857
  5 in total

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