Literature DB >> 8482370

Structural modifications associated with the change in Ca2+ sensitivity on activation of m-calpain.

N Brown1, C Crawford.   

Abstract

Autolysis of the Ca(2+)-dependent cysteine protease m-calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca2+ sensitivity. The appearance of increased Ca2+ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.

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Year:  1993        PMID： 8482370     DOI： 10.1016/0014-5793(93)81112-d

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

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2.  The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.

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Review 3.  Calpain system and its involvement in myocardial ischemia and reperfusion injury.

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4.  Purification of native p94, a muscle-specific calpain, and characterization of its autolysis.

Authors:  K Kinbara; S Ishiura; S Tomioka; H Sorimachi; S Y Jeong; S Amano; H Kawasaki; B Kolmerer; S Kimura; S Labeit; K Suzuki
Journal:  Biochem J       Date:  1998-11-01       Impact factor: 3.857

5.  Calcium-binding properties of human erythrocyte calpain.

Authors:  M Michetti; F Salamino; R Minafra; E Melloni; S Pontremoli
Journal:  Biochem J       Date:  1997-08-01       Impact factor: 3.857

6.  Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.

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7.  Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.

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8.  Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages.

Authors:  Zhi Huang; Fukun W Hoffmann; Robert L Norton; Ann C Hashimoto; Peter R Hoffmann
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9.  Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.

Authors:  Zhi Huang; Aaron H Rose; FuKun W Hoffmann; Ann S Hashimoto; Pietro Bertino; Tobias Denk; Jiro Takano; Nobuhisa Iwata; Takaomi C Saido; Peter R Hoffmann
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10.  The C2 domain of calpain 5 contributes to enzyme activation and membrane localization.

Authors:  Vimala Bondada; Jozsef Gal; Charles Mashburn; David W Rodgers; Katherine E Larochelle; Dorothy E Croall; James W Geddes
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2021-03-31       Impact factor: 5.011
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