Kinetics of antibody mediated suppression of humoral immune response to Toxoplasma gondii at a cellular level.

The effect of passively transferred Toxoplasma gondii antiserum was examined at a cellular level by rosette forming cell response in NMRI mouse spleen. The initial number of responding rosette forming cells was decreased in antibody treated animals; However, their rate of proliferation in comparison to untreated group was not significantly affected. Almost similar response could be obtained by injecting low 5 x 10(4) Toxoplasma dose alone or a combination of passive antibody and higher antigen dose of 1 x 10(6) parasites.