Literature DB >> 8477778

The possible role of sex hormones in the development of testicular cancer.

E Rajpert-De Meyts1, N E Skakkebaek.   

Abstract

The peak incidence of testicular cancer in young men suggests that gestational development and events during early infancy and puberty are important in the pathogenesis of the disease. There are two potentially significant events: the transformation of fetal germ cells into carcinoma-in-situ cells (CIS) and later conversion of CIS cells into fully invasive cancer. Several hypotheses suggest an endocrinological background to testicular neoplasia. Based on epidemiological and experimental evidence, the possible role of oestrogens, androgens and gonadotrophins is discussed in this review. The role of Sertoli cells and the importance of interplay between endocrine and paracrine factors is also stressed.

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Year:  1993        PMID： 8477778     DOI： 10.1159/000474570

Source DB:  PubMed          Journal:  Eur Urol        ISSN： 0302-2838            Impact factor:   20.096


  20 in total

1.  Marijuana use and testicular germ cell tumors.

Authors:  Britton Trabert; Alice J Sigurdson; Anne M Sweeney; Sara S Strom; Katherine A McGlynn
Journal:  Cancer       Date:  2010-10-05       Impact factor: 6.860

2.  Gestational age at birth and risk of testicular cancer.

Authors:  Casey Crump; Kristina Sundquist; Marilyn A Winkleby; Weiva Sieh; Jan Sundquist
Journal:  Int J Cancer       Date:  2011-09-14       Impact factor: 7.396

3.  Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of blood-testis barrier integrity in testicular carcinoma in situ.

Authors:  Cornelia Fink; Roswitha Weigel; Tanja Hembes; Heidrun Lauke-Wettwer; Sabine Kliesch; Martin Bergmann; Ralph H Brehm
Journal:  Neoplasia       Date:  2006-12       Impact factor: 5.715

4.  Baldness, acne and testicular germ cell tumours.

Authors:  B Trabert; A J Sigurdson; A M Sweeney; R J Amato; S S Strom; K A McGlynn
Journal:  Int J Androl       Date:  2010-12-03

5.  Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cells.

Authors:  Ralph Brehm; Christina Rüttinger; Petra Fischer; Isabella Gashaw; Elke Winterhager; Sabine Kliesch; Rainer M Bohle; Klaus Steger; Martin Bergmann
Journal:  Neoplasia       Date:  2006-06       Impact factor: 5.715

6.  Iatrogenic damage to male reproductive function.

Authors:  W F Hendry
Journal:  J R Soc Med       Date:  1995-10       Impact factor: 5.344

7.  The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline/glycine residues of synergy control motifs.

Authors:  Sarmistha Mukherjee; Osvaldo Cruz-Rodríguez; Eric Bolton; Jorge A Iñiguez-Lluhí
Journal:  J Biol Chem       Date:  2012-07-24       Impact factor: 5.157

8.  Testicular cancer, cryptorchidism, inguinal hernia, testicular atrophy, and genital malformations: case-control studies in Denmark.

Authors:  H Møller; A Prener; N E Skakkebaek
Journal:  Cancer Causes Control       Date:  1996-03       Impact factor: 2.506

9.  Genetic variation in the inhibin pathway and risk of testicular germ cell tumors.

Authors:  Mark P Purdue; Barry I Graubard; Stephen J Chanock; Mark V Rubertone; Ralph L Erickson; Katherine A McGlynn
Journal:  Cancer Res       Date:  2008-04-15       Impact factor: 12.701

10.  Association of marijuana use and the incidence of testicular germ cell tumors.

Authors:  Janet R Daling; David R Doody; Xiaofei Sun; Britton L Trabert; Noel S Weiss; Chu Chen; Mary L Biggs; Jacqueline R Starr; Sudhansu K Dey; Stephen M Schwartz
Journal:  Cancer       Date:  2009-03-15       Impact factor: 6.860
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