Literature DB >> 8477503

Amino acids and peptides. XVII. Synthesis of peptides related to N-terminal portion of fibrin alpha-chain and their inhibitory effect on fibrinogen/thrombin clotting.

K Kawasaki1, T Tsuji, K Hirase, M Miyano, S Inouye, M Iwamoto.   

Abstract

Various peptides related to N-terminal portion of fibrin alpha-chain were synthesized by the solution method and the solid-phase method, and their inhibitory effect on fibrinogen/thrombin clotting was examined. Extension of peptide chain from N-terminal tripeptide decreased the inhibitory effect. The most potent effect was shown by N-terminal decapeptide analog, H-Gly-Pro-Arg-Pro-Pro-Glu-Arg-His-Gln-Ser-NH2.

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Year:  1993        PMID： 8477503     DOI： 10.1248/cpb.41.525

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  1 in total

1.  Synthesis and Biological Evaluation of Cyclic [99mTc]-HYNIC-CGPRPPC as a Fibrin-Binding Peptide for Molecular Imaging of Thrombosis and Its Comparison with [99mTc]-HYNIC-GPRPP.

Authors:  Sedigheh Rezaeianpour; Atefeh Hajiagha Bozorgi; Abolghasem Moghimi; Ameneh Almasi; Saeed Balalaie; Sorour Ramezanpour; Sanaz Nasoohi; Seyed Mohammad Mazidi; Parham Geramifar; Ahmad Bitarafan-Rajabi; Soraya Shahhosseini
Journal:  Mol Imaging Biol       Date:  2017-04       Impact factor: 3.488
  1 in total

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