OBJECTIVE: To determine the distribution of platelet volumes and numbers through pregnancy, and to compare these to changes in platelet volumes and numbers in women with pre-eclampsia. SUBJECTS: Four hundred twenty-eight women with normal pregnancy from whom four or more platelet measurements were available were identified. 74 women with pre-eclampsia (blood pressure > or = 140/90 mmHg, at least 0.5 g protein/24 h urine collection) from whom platelet measurements were available between 27 and 30 weeks of gestation were identified. RESULTS: Mean platelet volume and platelet number remained constant in normal pregnancies between the first trimester and the end of pregnancy. A persistent increase of > or = 0.8 fl (> or = 90th centile) in mean platelet volume was found in 14 out of 15 pre-eclamptic patients between 24 weeks and 38 weeks of gestation and in only 13 of 428 normal pregnant individuals. Platelet numbers were decreased by > or = 50 x 10(9)/l (i.e. to less than the 10th centile) in 12 of the 15 patients with pre-eclampsia. 10% of the normal pregnant population showed a similar decline in platelet numbers showing that changes in platelet numbers may be a less accurate assessment of the development of pre-eclampsia. CONCLUSION: We suggest that longitudinal determination of platelet volumes may be of use in identifying those women at risk of pre-eclampsia.
OBJECTIVE: To determine the distribution of platelet volumes and numbers through pregnancy, and to compare these to changes in platelet volumes and numbers in women with pre-eclampsia. SUBJECTS: Four hundred twenty-eight women with normal pregnancy from whom four or more platelet measurements were available were identified. 74 women with pre-eclampsia (blood pressure > or = 140/90 mmHg, at least 0.5 g protein/24 h urine collection) from whom platelet measurements were available between 27 and 30 weeks of gestation were identified. RESULTS: Mean platelet volume and platelet number remained constant in normal pregnancies between the first trimester and the end of pregnancy. A persistent increase of > or = 0.8 fl (> or = 90th centile) in mean platelet volume was found in 14 out of 15 pre-eclamptic patients between 24 weeks and 38 weeks of gestation and in only 13 of 428 normal pregnant individuals. Platelet numbers were decreased by > or = 50 x 10(9)/l (i.e. to less than the 10th centile) in 12 of the 15 patients with pre-eclampsia. 10% of the normal pregnant population showed a similar decline in platelet numbers showing that changes in platelet numbers may be a less accurate assessment of the development of pre-eclampsia. CONCLUSION: We suggest that longitudinal determination of platelet volumes may be of use in identifying those women at risk of pre-eclampsia.
Authors: Piya Chaemsaithong; Roberto Romero; Adi L Tarca; Steven J Korzeniewski; Alyse G Schwartz; Jezid Miranda; Ahmed I Ahmed; Zhong Dong; Sonia S Hassan; Lami Yeo; Tinnakorn Tinnakorn Journal: J Matern Fetal Neonatal Med Date: 2014-09-29
Authors: Santiago Garcia-Tizon Larroca; Juan Arevalo-Serrano; Virginia Ortega Abad; Pilar Pintado Recarte; Alejandro Garcia Carreras; Gonzalo Nozaleda Pastor; Cesar Rodriguez Hernandez; Ricardo Perez Fernandez Pacheco; Juan De Leon Luis Journal: Open Access Maced J Med Sci Date: 2017-02-01