Literature DB >> 8476580

Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis.

M Z Himmelfarb1, D Zikk, Y Rapoport, C Redianu, I Shalit.   

Abstract

Following the fourth dose of 400 mg orally administered ofloxacin, simultaneous external ear canal granulation tissue and serum ofloxacin concentrations were estimated in 15 patients with invasive external otitis. The granulation tissue concentration was 2.2 (range 1.17-4.34) times higher than the serum concentration and 3.73 (range 1.95-11.00) times higher than the MIC90 of ofloxacin against Pseudomonas aeruginosa.

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Year:  1993        PMID： 8476580     DOI： 10.1007/bf02540111

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  14 in total

1.  Oral ofloxacin as treatment of malignant external otitis: a study of 17 cases.

Authors:  R Levy; T Shpitzer; J Shvero; S D Pitlik
Journal:  Laryngoscope       Date:  1990-05       Impact factor: 3.325

2.  The inhibitory quotient. A method for interpreting minimum inhibitory concentration data.

Authors:  P D Ellner; H C Neu
Journal:  JAMA       Date:  1981-10-02       Impact factor: 56.272

3.  Neurologic aspects of malignant external otitis: report of three cases.

Authors:  R P Dinapoli; J E Thomas
Journal:  Mayo Clin Proc       Date:  1971-05       Impact factor: 7.616

4.  Ciprofloxacin treatment of malignant external otitis.

Authors:  J Sadé; R Lang; S Goshen; R Kitzes-Cohen
Journal:  Am J Med       Date:  1989-11-30       Impact factor: 4.965

5.  Malignant external otitis.

Authors:  A Babiatzki; J Sadé
Journal:  J Laryngol Otol       Date:  1987-03       Impact factor: 1.469

6.  Oral ofloxacin therapy for invasive external otitis.

Authors:  D Zikk; Y Rapoport; C Redianu; I Shalit; M Z Himmelfarb
Journal:  Ann Otol Rhinol Laryngol       Date:  1991-08       Impact factor: 1.547

7.  Treatment of invasive external otitis with cefsulodin.

Authors:  M H Mendelson; B R Meyers; S Z Hirschman; E R Shapiro; S C Parisier
Journal:  Rev Infect Dis       Date:  1984 Sep-Oct

8.  Invasive external otitis. Report of 21 cases and review of the literature.

Authors:  R M Doroghazi; J B Nadol; N E Hyslop; A S Baker; L Axelrod
Journal:  Am J Med       Date:  1981-10       Impact factor: 4.965

Review 9.  Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  J P Monk; D M Campoli-Richards
Journal:  Drugs       Date:  1987-04       Impact factor: 9.546

10.  Malignant external otitis. Comparison of monotherapy vs combination therapy.

Authors:  B R Meyers; M H Mendelson; S C Parisier; S Z Hirschman
Journal:  Arch Otolaryngol Head Neck Surg       Date:  1987-09
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