Literature DB >> 84764

Sensitivity of human lymphocytes to bleomycin increases with age.

R S Seshadri, A A Morley, K J Trainor, J Sorrell.   

Abstract

The sensitivity of human peripheral blood lymphocytes to bleomycin and mitomycin-C was assessed by measuring the inhibition of phytohemagglutinin stimulated proliferation. The sensitivity to bleomycin, and not to mitomycin-C, increased with the age.

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Year:  1979        PMID： 84764     DOI： 10.1007/BF01920635

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  The thermal degradation of nucleic acids.

Authors:  J EIGNER; H BOEDTKER; G MICHAELS
Journal:  Biochim Biophys Acta       Date:  1961-07-22

2.  Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.

Authors:  S Linn; M Kairis; R Holliday
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

3.  Altered rate of DNA replication in ageing human fibroblast cultures.

Authors:  T D Petes; R A Farber; G M Tarrant; R Holliday
Journal:  Nature       Date:  1974-10-04       Impact factor: 49.962

4.  Young and old rats. ATP, alkaline phosphatase, cholesterol and protein levels in the blood; DNA and RNA contents of the liver. Regulation by an aqueous thymus extract.

Authors:  D Amici; G L Gianfranceschi; G Marsili; L Michetti
Journal:  Experientia       Date:  1974-06-15

Review 5.  The regulation of protein synthesis in the ageing cell.

Authors:  H P von Hahn
Journal:  Exp Gerontol       Date:  1970-12       Impact factor: 4.032

6.  Changes in the structure of rat liver DNA in relation to age.

Authors:  H R Massie; M B Baird; R J Nicolosi; H V Samis
Journal:  Arch Biochem Biophys       Date:  1972-12       Impact factor: 4.013

7.  Bleomycin causes release of nucleosomes from chromatin and chromosomes.

Authors:  M T Kuo; T C Hsu
Journal:  Nature       Date:  1978-01-05       Impact factor: 49.962

8.  Is aplastic anaemia due to abnormality of D.N.A.?

Authors:  A Morley; R Seshadri; K Trainor; J Sorrell
Journal:  Lancet       Date:  1978-07-01       Impact factor: 79.321

9.  On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro.

Authors:  H Suzuki; K Nagai; E Akutsu; H Yamaki; N Tanaka
Journal:  J Antibiot (Tokyo)       Date:  1970-10       Impact factor: 2.649

10.  Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.

Authors:  R W Hart; R B Setlow
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205
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