[Synthesis and biological activity of 1,5-diaryl-3-alkylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones and 1,5-diaryl-4-carboxymethyltetrahydropyrrol-2,3-diones].

By interaction of alpha-ketoglutaric acid with Schiff bases 1,5-diaryl-3-arylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones 1 were obtained. Hydrolysis of the latter, carried out with hydrochloride acid gave 1,5-diaryl-3-hydroxy-4-carboxymethyl-2,5-dihydropyrrol-2-ones 2. On treatment of 2 with aryl-amines the starting compounds 1 were yielded. All compounds were tested for their antiphlogistic activity.