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Literature DB >> 8475089

Mapping cis-acting defects in promoters of transcriptionally silent DQA2, DQB2, and DOB genes.

Abstract

Defects in promoters of the nonexpressed DQA2, DQB2, and DOB genes from the class II major histo-compatibility complex were mapped by placing Z and X boxes of these silent genes into a synthetic DRA promoter. These conserved upstream sequences confer B-cell-specific and gamma-interferon-inducible expression to the DRA gene. Since DRA promoters containing the X box from the DQA2 gene and Z boxes from DQA2, DQB2, and DOB genes were neither expressed constitutively in B cells nor inducible by gamma interferon in fibroblastic cells, these conserved upstream sequences are implicated in the transcriptional defects of these silent genes.

Entities: Gene

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Year: 1993 PMID： 8475089 PMCID： PMC46309 DOI： 10.1073/pnas.90.8.3408

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors.

Authors: S Y Tsang; M Nakanishi; B M Peterlin
Journal: Mol Cell Biol Date: 1990-02 Impact factor: 4.272

2. Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC.

Authors: J Berdoz; J M Tiercy; P Rollini; B Mach; J Gorski
Journal: Immunogenetics Date: 1989 Impact factor: 2.846

3. Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family.

Authors: B Servenius; L Rask; P A Peterson
Journal: J Biol Chem Date: 1987-06-25 Impact factor: 5.157

4. A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.

Authors: H C Liou; M R Boothby; P W Finn; R Davidon; N Nabavi; N J Zeleznik-Le; J P Ting; L H Glimcher
Journal: Science Date: 1990-03-30 Impact factor: 47.728

5. Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation.

Authors: W Reith; E Barras; S Satola; M Kobr; D Reinhart; C H Sanchez; B Mach
Journal: Proc Natl Acad Sci U S A Date: 1989-06 Impact factor: 11.205

6. Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.

Authors: C Auffray; J W Lillie; A J Korman; J M Boss; N Fréchin; F Guillemot; J Cooper; R C Mulligan; J L Strominger
Journal: Immunogenetics Date: 1987 Impact factor: 2.846

7. B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

Authors: S Y Tsang; M Nakanishi; B M Peterlin
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

Review 8. Human class II major histocompatibility complex genes and proteins.

Authors: D Kappes; J L Strominger
Journal: Annu Rev Biochem Date: 1988 Impact factor: 23.643

9. Class II genes of the human major histocompatibility complex. Organization and evolutionary relationship of the DR beta genes.

Authors: G Andersson; D Larhammar; E Widmark; B Servenius; P A Peterson; L Rask
Journal: J Biol Chem Date: 1987-06-25 Impact factor: 5.157

10. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

Authors: L Osborn; S Kunkel; G J Nabel
Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205

3 in total