Literature DB >> 8474063

Dicyanogold (I) is a common human metabolite of different gold drugs.

R C Elder1, Z Zhao, Y Zhang, J G Dorsey, E V Hess, K Tepperman.   

Abstract

Gold based drugs and their metabolites have been characterized using reversed phase, ion pairing chromatography with an inductively coupled plasma mass spectrometer as an element specific detector. For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood. The same compound is also identified in the urine and blood of a patient taking auranofin and in patients taking solganol. This represents the first identification of a specific gold metabolite in biological fluids taken from patients undergoing gold therapy and the first evidence that different gold drugs have common metabolites.

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Year:  1993        PMID: 8474063

Source DB:  PubMed          Journal:  J Rheumatol        ISSN: 0315-162X            Impact factor:   4.666


  4 in total

1.  A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]- to human serum albumin.

Authors:  Jihan Talib; Jennifer L Beck; Stephen F Ralph
Journal:  J Biol Inorg Chem       Date:  2006-05-12       Impact factor: 3.358

2.  In vitro liberation of charged gold atoms: autometallographic tracing of gold ions released by macrophages grown on metallic gold surfaces.

Authors:  Agnete Larsen; Meredin Stoltenberg; Gorm Danscher
Journal:  Histochem Cell Biol       Date:  2007-06-05       Impact factor: 4.304

Review 3.  Anticancer activity of metal complexes: involvement of redox processes.

Authors:  Ute Jungwirth; Christian R Kowol; Bernhard K Keppler; Christian G Hartinger; Walter Berger; Petra Heffeter
Journal:  Antioxid Redox Signal       Date:  2011-05-11       Impact factor: 8.401

4.  Ex vivo effect of gold nanoparticles on porcine synovial membrane.

Authors:  Raphael Labens; B Duncan X Lascelles; Anna N Charlton; Nicole R Ferrero; Arnaud J Van Wettere; Xin-Riu Xia; Anthony T Blikslager
Journal:  Tissue Barriers       Date:  2013-04-01
  4 in total

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