| Literature DB >> 8473453 |
Abstract
A prospective randomized study was conducted at the Family Planning Association of Hong Kong to compare the efficacy of the Yuzpe regimen and levonorgestrel (0.75 mg for two doses 12 h apart) in post-coital contraception. A total of 424 subjects were recruited into the Yuzpe group and 410 subjects into the levonorgestrel group; 77 subjects in the Yuzpe group and 79 subjects in the levonorgestrel group had further acts of intercourse during the treatment cycle. Fifteen pregnancies (3.5%) occurred in the Yuzpe group and 12 pregnancies (2.9%) in the levonorgestrel group. After excluding the patients who had further acts of intercourse, the failure rates in the Yuzpe group and the levonorgestrel group were 2.6 and 2.4% respectively. The incidence of nausea, vomiting and fatigue in the Yuzpe group was significantly higher than those in the levonorgestrel group. We conclude that levonorgestrel is an effective drug for post-coital contraception with a lower incidence of side-effects than the Yuzpe regimen.Entities:
Keywords: Asia; Comparative Studies; Contraception; Contraceptive Agents, Estrogen--administraction and dosage; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents--administraction and dosage; Demographic Factors; Developing Countries; Eastern Asia; Ethinyl Estradiol--administraction and dosage; Family Planning; Fertility; Fertility Control, Postcoital; Fertility Measurements; Hong Kong; Levonorgestrel--administraction and dosage; Norgestrel--administraction and dosage; Population; Population Dynamics; Pregnancy Rate; Prospective Studies; Research Methodology; Studies
Mesh：
Substances：
Year: 1993 PMID： 8473453 DOI： 10.1093/oxfordjournals.humrep.a138057
Source DB: PubMed Journal: Hum Reprod ISSN： 0268-1161 Impact factor: 6.918