Literature DB >> 8472025

Synthesis of 6-[18F] and 4-[18F]fluoro-L-m-tyrosines via regioselective radiofluorodestannylation.

M Namavari1, N Satyamurthy, M E Phelps, J R Barrio.   

Abstract

The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative 6 with [18F]F2 and [18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[18F]fluoro-L-m-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[18F]fluoro-L-m-tyrosine (13a) was synthesized in 11% radiochemical yield from the corresponding 4-trimethylstannyl-L-m-tyrosine derivative 11 using [18F]F2. The structural analyses of precursors (6,11), intermediates, and the final products (after 18F decay), were carried out by 1H, 13C, 19F, 119Sn-NMR and high resolution mass spectroscopy.

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Year:  1993        PMID： 8472025     DOI： 10.1016/0969-8043(93)90165-7

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  9 in total

1.  A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease.

Authors:  Catherine L Gallagher; Bradley T Christian; James E Holden; Onofre T Dejesus; Robert J Nickles; Laura Buyan-Dent; Barbara B Bendlin; Sandra J Harding; Charles K Stone; Barb Mueller; Sterling C Johnson
Journal:  Mov Disord       Date:  2011-06-02       Impact factor: 10.338

2.  Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.

Authors:  Massimo S Fiandaca; Vanja Varenika; Jamie Eberling; Tracy McKnight; John Bringas; Phillip Pivirotto; Janine Beyer; Piotr Hadaczek; William Bowers; John Park; Howard Federoff; John Forsayeth; Krystof S Bankiewicz
Journal:  Neuroimage       Date:  2008-11-27       Impact factor: 6.556

3.  A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson's disease.

Authors:  Clarence T Li; Matthew Palotti; James E Holden; Jen Oh; Ozioma Okonkwo; Bradley T Christian; Barbara B Bendlin; Laura Buyan-Dent; Sandra J Harding; Charles K Stone; Onofre T DeJesus; Robert J Nickles; Catherine L Gallagher
Journal:  Synapse       Date:  2014-04-22       Impact factor: 2.562

4.  Molecular imaging probe development: a chemistry perspective.

Authors:  Donald D Nolting; Michael L Nickels; Ning Guo; Wellington Pham
Journal:  Am J Nucl Med Mol Imaging       Date:  2012-07-10

5.  Striatal dopamine and working memory.

Authors:  Susan M Landau; Rayhan Lal; James P O'Neil; Suzanne Baker; William J Jagust
Journal:  Cereb Cortex       Date:  2008-06-11       Impact factor: 5.357

6.  Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.

Authors:  Jamie L Eberling; Adrian P Kells; Philip Pivirotto; Janine Beyer; John Bringas; Howard J Federoff; John Forsayeth; Krystof S Bankiewicz
Journal:  Hum Gene Ther       Date:  2009-05       Impact factor: 5.695

7.  Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration.

Authors:  Roshan Cools; Michael J Frank; Sasha E Gibbs; Asako Miyakawa; William Jagust; Mark D'Esposito
Journal:  J Neurosci       Date:  2009-02-04       Impact factor: 6.167

8.  PET 6-[F]fluoro-L-m-tyrosine Studies of Dopaminergic Function in Human and Nonhuman Primates.

Authors:  Jamie L Eberling; Krystof S Bankiewicz; James P O'Neil; William J Jagust
Journal:  Front Hum Neurosci       Date:  2008-03-28       Impact factor: 3.169

9.  Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides.

Authors:  Benjamin H Rotstein; Lu Wang; Richard Y Liu; Jon Patteson; Eugene E Kwan; Neil Vasdev; Steven H Liang
Journal:  Chem Sci       Date:  2016-03-24       Impact factor: 9.825
  9 in total

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