Literature DB >> 8471412

Bronchodilating effects of the novel potassium channel opener HOE 234 in human airways in vitro.

M Miura1, M G Belvisi, J K Ward, S Tadjkarimi, M H Yacoub, P J Barnes.   

Abstract

Bronchodilating effects of the novel potassium channel opener HOE 234 were examined in human bronchi in vitro and compared with those of BRL 38227. HOE 234 produced concentration-dependent relaxations of spontaneous tone and of tone increased by methacholine (10(-6) M), with mean EC50 values of 11 nM and 47 nM, respectively (n = 5). The relaxation produced by HOE 234 was 7 and 3.5 fold more potent than that by BRL 38227 on spontaneous and induced tone, respectively, and was inhibited by glibenclamide (10(-5) M). These results suggest that HOE 234 is a potent bronchodilator which activates ATP-sensitive potassium channels in human airways.

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Year:  1993        PMID： 8471412      PMCID： PMC1381584          DOI： 10.1111/j.1365-2125.1993.tb05701.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  9 in total

1.  Role of potassium channels in bronchodilator responses in human airways.

Authors:  M Miura; M G Belvisi; C D Stretton; M H Yacoub; P J Barnes
Journal:  Am Rev Respir Dis       Date:  1992-07

2.  The action of a potassium channel activator, BRL 38227 (lemakalim), on human airway smooth muscle.

Authors:  J L Black; C L Armour; P R Johnson; L A Alouan; P J Barnes
Journal:  Am Rev Respir Dis       Date:  1990-12

3.  Potassium currents in canine airway smooth muscle cells.

Authors:  M I Kotlikoff
Journal:  Am J Physiol       Date:  1990-12

Review 4.  Potassium channels and airway function: new therapeutic prospects.

Authors:  J L Black; P J Barnes
Journal:  Thorax       Date:  1990-03       Impact factor: 9.139

Review 5.  The pharmacology of potassium channels and their therapeutic potential.

Authors:  N S Cook
Journal:  Trends Pharmacol Sci       Date:  1988-01       Impact factor: 14.819

6.  Calcium-activated potassium channels in canine airway smooth muscle.

Authors:  J D McCann; M J Welsh
Journal:  J Physiol       Date:  1986-03       Impact factor: 5.182

Review 7.  Adenosine 5'-triphosphate-sensitive potassium channels.

Authors:  F M Ashcroft
Journal:  Annu Rev Neurosci       Date:  1988       Impact factor: 12.449

8.  Airway pharmacology of the potassium channel opener, HOE 234, in guinea pigs: in vitro and in vivo studies.

Authors:  H C Englert; K Wirth; D Gehring; U Fürst; U Albus; W Scholz; B Rosenkranz; B A Schölkens
Journal:  Eur J Pharmacol       Date:  1992-01-07       Impact factor: 4.432

9.  Attenuation of nocturnal asthma by cromakalim.

Authors:  A J Williams; T H Lee; G M Cochrane; A Hopkirk; T Vyse; F Chiew; E Lavender; D H Richards; S Owen; P Stone
Journal:  Lancet       Date:  1990-08-11       Impact factor: 79.321
  9 in total
  2 in total

1.  Cromakalim inhibits transmitter acetylcholine release in rat trachea by an action on epithelial cells and a diffusible factor.

Authors:  Ross Vlahos; Maurice E Fabiani; David F Story
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-09-18       Impact factor: 3.000

2.  Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles.

Authors:  Bahman Emami; Farzaneh Shakeri; Zahra Gholamnezhad; Saeideh Saadat; Marzie Boskabady; Vahab Azmounfar; Hamed Sadatfaraji; Mohammad Hossein Boskabady
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.503
  2 in total

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