Literature DB >> 8470332

Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys.

C G Stief1, F Benard, R Bosch, S Aboseif, U Wetterauer, T F Lue, E A Tanagho.   

Abstract

The distribution of calcitonin gene-related peptide (CGRP) immunoreactivity in the cavernous tissue and the erectile response to intracavernous injection of CGRP was investigated in 7 monkeys. Intracavernous CGRP increased cavernous arterial flow and induced cavernous smooth muscle relaxation and venous outflow occlusion. Intracavernous injection of CGRP antibody did not significantly change the erectile response to cavernous nerve stimulation. Histologic staining for CGRP immunoreactivity showed nerve fiber-like staining within the cavernous arterial wall and the cavernous smooth muscles. These data suggest that CGRP may contribute to penile erection in monkeys.

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Year:  1993        PMID： 8470332     DOI： 10.1016/0090-4295(93)90608-d

Source DB:  PubMed          Journal:  Urology        ISSN： 0090-4295            Impact factor:   2.649


  9 in total

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  9 in total

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