Literature DB >> 8468391

Determination of boldine in plasma by high-performance liquid chromatography.

H Speisky1, B K Cassels, S Nieto, A Valenzuela, L J Nuñez-Vergara.   

Abstract

A sensitive method for the determination of boldine in blood plasma is described. The procedure involves a direct pH-buffered chloroform extraction of boldine from blood plasma, followed by its assay under isocratic conditions by HPLC with UV detection. The extraction recovery is excellent, and sensitivity and precision of the method are very high, when applied to plasma samples containing pharmacologically relevant concentrations of boldine.

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Year:  1993        PMID： 8468391     DOI： 10.1016/0378-4347(93)80179-8

Source DB:  PubMed          Journal:  J Chromatogr


  3 in total

1.  Anti-inflammatory and antipyretic effects of boldine.

Authors:  N Backhouse; C Delporte; M Givernau; B K Cassels; A Valenzuela; H Speisky
Journal:  Agents Actions       Date:  1994-10

2.  Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes.

Authors:  R Bannach; A Valenzuela; B K Cassels; L J Nunez-Vergara; H Speisky
Journal:  Cell Biol Toxicol       Date:  1996-04       Impact factor: 6.691

3.  Boldine prevents renal alterations in diabetic rats.

Authors:  Romina Hernández-Salinas; Alejandra Z Vielma; Marlene N Arismendi; Mauricio P Boric; Juan C Sáez; Victoria Velarde
Journal:  J Diabetes Res       Date:  2013-12-12       Impact factor: 4.011
  3 in total

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